Dcaf6 DDB1 and CUL4 associated factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf6provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 6provided by MGI
Primary source: MGI:MGI:1921356
See related: Ensembl:ENSMUSG00000026571 AllianceGenome:MGI:1921356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iqwd1; PC326; 1200006M05Rik
Summary: Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF6 (DDB1 and CUL4 associated factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 41.3), cortex adult (RPKM 13.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.2- H2.3; 1 72.67 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (165157069..165288475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (165329500..165460906, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.
Title: Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.
we demonstrated that deprivation of NRIP decreases myogenin expression at NMJ, possibly leading to abnormal NMJ formation, denervation of acetylcholine receptor, and subsequent loss of spinal motor neuron.
Title: Muscle-restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down-regulation of myogenin at the neuromuscular junction.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 6

Names: IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; NRIP; nuclear receptor interaction protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028759.1 → NP_083035.1 DDB1- and CUL4-associated factor 6

See identical proteins and their annotated locations for NP_083035.1

Status: VALIDATED

Source sequence(s)

AC116374, AC162789

Consensus CDS

CCDS48424.1

UniProtKB/Swiss-Prot

Q8BK50, Q9DC22

Related

ENSMUSP00000027856.8, ENSMUST00000027856.13

Conserved Domains (3) summary

COG2319
Location:42 → 281

WD40; WD40 repeat [General function prediction only]

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl02567
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

165157069..165288475 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243204.1 → XP_030099064.1 DDB1- and CUL4-associated factor 6 isoform X7

Conserved Domains (2) summary

sd00039
Location:48 → 99

7WD40; WD40 repeat [structural motif]

cl29593
Location:5 → 145

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153945.1 → XP_036009838.1 DDB1- and CUL4-associated factor 6 isoform X8

Conserved Domains (1) summary

cl29593
Location:599 → 658

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153915.1 → XP_036009808.1 DDB1- and CUL4-associated factor 6 isoform X1

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153926.1 → XP_036009819.1 DDB1- and CUL4-associated factor 6 isoform X3

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153932.1 → XP_036009825.1 DDB1- and CUL4-associated factor 6 isoform X5

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153933.1 → XP_036009826.1 DDB1- and CUL4-associated factor 6 isoform X6

Conserved Domains (2) summary

sd00039
Location:48 → 99

7WD40; WD40 repeat [structural motif]

cl29593
Location:5 → 145

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153936.1 → XP_036009829.1 DDB1- and CUL4-associated factor 6 isoform X6

Conserved Domains (2) summary

sd00039
Location:48 → 99

7WD40; WD40 repeat [structural motif]

cl29593
Location:5 → 145

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006497004.3 → XP_006497067.1 DDB1- and CUL4-associated factor 6 isoform X2

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006497005.3 → XP_006497068.1 DDB1- and CUL4-associated factor 6 isoform X4

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006497008.3 → XP_006497071.1 DDB1- and CUL4-associated factor 6 isoform X9

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036153948.1 → XP_036009841.1 DDB1- and CUL4-associated factor 6 isoform X9

Conserved Domains (2) summary

sd00039
Location:55 → 92

7WD40; WD40 repeat [structural motif]

cl29593
Location:43 → 292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...