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    Spats2l spermatogenesis associated, serine-rich 2-like [ Mus musculus (house mouse) ]

    Gene ID: 67198, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spats2lprovided by MGI
    Official Full Name
    spermatogenesis associated, serine-rich 2-likeprovided by MGI
    Primary source
    MGI:MGI:1914448
    See related
    Ensembl:ENSMUSG00000038305 AllianceGenome:MGI:1914448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810022L02Rik; A230104H11Rik
    Summary
    Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; cranium; foot mesenchyme; foregut; and genitourinary system. Orthologous to human SPATS2L (spermatogenesis associated serine rich 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 12.7), CNS E18 (RPKM 5.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spats2l in Genome Data Viewer
    Location:
    1 C1.3; 1 28.85 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57813261..57987557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57774102..57948398)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17929 Neighboring gene STARR-seq mESC enhancer starr_00995 Neighboring gene predicted gene, 57573 Neighboring gene STARR-seq mESC enhancer starr_00996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:57896765-57896993 Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene potassium channel tetramerisation domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SPATS2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164566.1 → NP_001158038.1  SPATS2-like protein isoform 2

      See identical proteins and their annotated locations for NP_001158038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, uses an downstream translational start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC110735, AC112971, AK032169, BE335142, BY069430, BY634273, BY739337, CK624383, CN698528
      Consensus CDS
      CCDS48267.1
      UniProtKB/TrEMBL
      E9PZE9
      Related
      ENSMUSP00000132975.2, ENSMUST00000169772.3
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 368
      DUF1387; Protein of unknown function (DUF1387)

    2. NM_001368787.1 → NP_001355716.1  SPATS2-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110735, AC112971, AC157804
      UniProtKB/Swiss-Prot
      Q8K322, Q8VC37, Q91WJ7
      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 368
      DUF1387; Protein of unknown function (DUF1387)

    3. NM_144882.4 → NP_659131.2  SPATS2-like protein isoform 1

      See identical proteins and their annotated locations for NP_659131.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC110735, AC157804, AK032169, BY317793, BY634273
      Consensus CDS
      CCDS35573.2
      UniProtKB/TrEMBL
      E9PVQ3, E9PZE9
      Related
      ENSMUSP00000133054.2, ENSMUST00000167085.8
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 388
      DUF1387; Protein of unknown function (DUF1387)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      57813261..57987557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496210.5 → XP_006496273.1  SPATS2-like protein isoform X2

      See identical proteins and their annotated locations for XP_006496273.1

      UniProtKB/TrEMBL
      E9PVQ3, E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 388
      DUF1387; Protein of unknown function (DUF1387)

    2. XM_017322123.2 → XP_017177612.1  SPATS2-like protein isoform X3

      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 387
      DUF1387; Protein of unknown function (DUF1387)

    3. XM_006496217.5 → XP_006496280.1  SPATS2-like protein isoform X5

      See identical proteins and their annotated locations for XP_006496280.1

      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 318
      DUF1387; Protein of unknown function (DUF1387)

    4. XM_006496211.5 → XP_006496274.1  SPATS2-like protein isoform X2

      See identical proteins and their annotated locations for XP_006496274.1

      UniProtKB/TrEMBL
      E9PVQ3, E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 388
      DUF1387; Protein of unknown function (DUF1387)

    5. XM_030242305.1 → XP_030098165.1  SPATS2-like protein isoform X3

      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 387
      DUF1387; Protein of unknown function (DUF1387)

    6. XM_036153073.1 → XP_036008966.1  SPATS2-like protein isoform X1

      UniProtKB/TrEMBL
      E9PZE9
      Related
      ENSMUSP00000127598.2, ENSMUST00000170139.8
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 368
      DUF1387; Protein of unknown function (DUF1387)

    7. XM_006496212.4 → XP_006496275.1  SPATS2-like protein isoform X2

      See identical proteins and their annotated locations for XP_006496275.1

      UniProtKB/TrEMBL
      E9PVQ3, E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 388
      DUF1387; Protein of unknown function (DUF1387)

    8. XM_006496218.5 → XP_006496281.1  SPATS2-like protein isoform X4

      See identical proteins and their annotated locations for XP_006496281.1

      UniProtKB/Swiss-Prot
      Q8K322, Q8VC37, Q91WJ7
      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 368
      DUF1387; Protein of unknown function (DUF1387)

    9. XM_006496216.5 → XP_006496279.1  SPATS2-like protein isoform X5

      See identical proteins and their annotated locations for XP_006496279.1

      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 318
      DUF1387; Protein of unknown function (DUF1387)

    10. XM_030242308.1 → XP_030098168.1  SPATS2-like protein isoform X6

      UniProtKB/TrEMBL
      E9PZE9
      Related
      ENSMUSP00000132592.2, ENSMUST00000164302.8
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 318
      DUF1387; Protein of unknown function (DUF1387)

    11. XM_017322122.3 → XP_017177611.1  SPATS2-like protein isoform X3

      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 387
      DUF1387; Protein of unknown function (DUF1387)

    12. XM_036153076.1 → XP_036008969.1  SPATS2-like protein isoform X2

      UniProtKB/TrEMBL
      E9PVQ3, E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:79 → 388
      DUF1387; Protein of unknown function (DUF1387)

    13. XM_036153087.1 → XP_036008980.1  SPATS2-like protein isoform X4

      UniProtKB/Swiss-Prot
      Q8K322, Q8VC37, Q91WJ7
      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 368
      DUF1387; Protein of unknown function (DUF1387)

    14. XM_006496215.5 → XP_006496278.1  SPATS2-like protein isoform X4

      See identical proteins and their annotated locations for XP_006496278.1

      UniProtKB/Swiss-Prot
      Q8K322, Q8VC37, Q91WJ7
      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 368
      DUF1387; Protein of unknown function (DUF1387)

    15. XM_030242309.2 → XP_030098169.1  SPATS2-like protein isoform X7

      UniProtKB/TrEMBL
      E9PZE9
      Conserved Domains (1) summary
      pfam07139
      Location:59 → 298
      DUF1387; Protein of unknown function (DUF1387)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WJ7.2 GenPept UniProtKB/Swiss-Prot:Q91WJ7

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