grhl2 grainyhead like transcription factor 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: grhl2provided by Xenbase
Official Full Name: grainyhead like transcription factor 2provided by Xenbase
Primary source: Xenbase:XB-GENE-485995
See related: Ensembl:ENSXETG00000006632 AllianceGenome:Xenbase:XB-GENE-485995
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: bom; dfna28; tfcp2l3
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including bicellular tight junction assembly; epithelial cell morphogenesis; and neural tube closure. Predicted to be located in cell-cell junction. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (131044244..131091656)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (118984406..119031661, complement)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables intronic transcription regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: grainyhead-like protein 2 homolog

Names: grainyhead 2; grainyhead-like 2; transcription factor CP2-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011338.1 → NP_001011338.1 grainyhead-like protein 2 homolog

See identical proteins and their annotated locations for NP_001011338.1

Status: PROVISIONAL

Source sequence(s)

BC088489

UniProtKB/Swiss-Prot

Q28D77, Q5M7R9

UniProtKB/TrEMBL

A0A6I8RFI6

Related

ENSXETP00000073080.1, ENSXETT00000081463.2

Conserved Domains (1) summary

pfam04516
Location:224 → 433

CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

131044244..131091656

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031903347.1 → XP_031759207.1 grainyhead-like protein 2 homolog isoform X2

UniProtKB/TrEMBL

A0A6I8RFI6, A0A8J1JMU8

Conserved Domains (1) summary

pfam04516
Location:224 → 433

CP2; CP2 transcription factor
XM_031903346.1 → XP_031759206.1 grainyhead-like protein 2 homolog isoform X1

UniProtKB/TrEMBL

A0A6I8RFI6, A0A8J1JRJ3

Conserved Domains (1) summary

pfam04516
Location:224 → 432

CP2; CP2 transcription factor