Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Celsr1provided by RGD
Official Full Name: cadherin, EGF LAG seven-pass G-type receptor 1provided by RGD
Primary source: RGD:1560078
See related: EnsemblRapid:ENSRNOG00000021285 AllianceGenome:RGD:1560078
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in cell-cell adhesion and establishment of planar polarity. Predicted to act upstream of or within several processes, including Rho protein signal transduction; apical protein localization; and morphogenesis of an epithelium. Predicted to be located in nucleoplasm and plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 53.4), Lung (RPKM 43.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (118867450..119004859, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (116987616..117125035, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (126774010..126914085, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway.
Title: CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132102 (e-PCR)
- UniSTS:215385

RH131921 (e-PCR)
- UniSTS:215204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apical protein localization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of body hair planar orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of planar polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of planar polarity of embryonic epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral sprouting involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization involved in establishment of planar polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin EGF LAG seven-pass G-type receptor 1

Names: cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); flamingo-like protein celsr1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427591.1 → NP_001414520.1 cadherin EGF LAG seven-pass G-type receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HTF9, F1MAS4

Related

ENSRNOP00000029944.6, ENSRNOT00000036025.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

118867450..119004859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080317.2 → XP_038936245.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

UniProtKB/TrEMBL

A6HTF9

Conserved Domains (13) summary

smart00303
Location:2422 → 2475

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:808 → 903

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2067 → 2128

HormR; Domain present in hormone receptors

smart00179
Location:1923 → 1961

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:1889 → 1923

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2017 → 2055

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1459 → 1642

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00185
Location:1951 → 2000

TNFRSF; CRD3 [structural motif]

pfam02210
Location:1734 → 1864

Laminin_G_2; Laminin G domain

pfam16489
Location:2145 → 2396

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:2482 → 2507

7tm_GPCRs; TM helix 1 [structural motif]

cl22855
Location:1930 → 2026

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

cl28897
Location:2480 → 2733

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063263331.1 → XP_063119401.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

UniProtKB/TrEMBL

A6HTF9
XM_006242167.5 → XP_006242229.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006242229.1

UniProtKB/TrEMBL

A6HTF9

Conserved Domains (10) summary

smart00303
Location:2422 → 2475

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:808 → 903

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2067 → 2128

HormR; Domain present in hormone receptors

cd00054
Location:1889 → 1923

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2017 → 2055

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1459 → 1642

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00002
Location:2509 → 2712

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02210
Location:1734 → 1864

Laminin_G_2; Laminin G domain

pfam16489
Location:2146 → 2394

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl22855
Location:1930 → 2026

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024251.1: Suppressed sequence

Description

NM_001024251.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.