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    vap RAS p21 protein activator vap [ Musca domestica (house fly) ]

    Gene ID: 101901421, updated on 22-Jun-2024

    Summary

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    Gene symbol
    vap
    Gene description
    RAS p21 protein activator vap
    See related
    VectorBase:MDOMA2_015742
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Musca domestica
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea; Muscidae; Musca
    Orthologs
    fruit fly all
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    Genomic context

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    See vap in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_08 current Musca_domestica.polishedcontigs.V.1.1 (GCF_030504385.1) Unplaced Scaffold NW_026712250.1 (13682895..13737879, complement)
    102 previous assembly Musca_domestica-2.0.2 (GCF_000371365.1) Unplaced Scaffold NW_004765091.1 (22229..91568)

    NW_026712250.1Genomic Context describing neighboring genes Neighboring gene serine-rich adhesin for platelets Neighboring gene uncharacterized LOC131802340 Neighboring gene uncharacterized LOC131802339 Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene putative uncharacterized protein DDB_G0277255 Neighboring gene nucleoplasmin-like protein ANO39 Neighboring gene ribosomal protein L17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic Analysis of Musca domestica to Reveal Key Genes of the Prophenoloxidase-Activating System. Li D, et al. G3 (Bethesda), 2015 Jul 7. PMID 26156588, Free PMC Article
    2. Transcriptomic analysis of the housefly (Musca domestica) larva using massively parallel pyrosequencing. Liu F, et al. Mol Biol Rep, 2012 Feb. PMID 21643958
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating protein 1
    Names
    GTPase-activator protein for Ras-like GTPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_030504385.1-RS_2023_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Musca_domestica.polishedcontigs.V.1.1 Primary Assembly

    Genomic

    1. NW_026712250.1 Reference Musca_domestica.polishedcontigs.V.1.1 Primary Assembly

      Range
      13682895..13737879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011294278.3 → XP_011292580.1  ras GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1I8M310
      Conserved Domains (8) summary
      cd08400
      Location:505 → 628
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:70 → 172
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:258 → 332
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:189 → 247
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      smart00323
      Location:611 → 959
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13260
      Location:385 → 490
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:387 → 491
      PH; PH domain
      cl02569
      Location:626 → 960
      RasGAP; Ras GTPase Activating Domain

    2. XM_005183622.4 → XP_005183679.1  ras GTPase-activating protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005183679.1

      UniProtKB/TrEMBL
      T1PEB8
      Conserved Domains (8) summary
      cd08400
      Location:501 → 624
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:66 → 168
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:254 → 328
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:185 → 243
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      smart00323
      Location:607 → 955
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13260
      Location:381 → 486
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:383 → 487
      PH; PH domain
      cl02569
      Location:622 → 956
      RasGAP; Ras GTPase Activating Domain

    3. XM_005183620.3 → XP_005183677.1  ras GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1I8M309
      Conserved Domains (8) summary
      cd08400
      Location:563 → 686
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10354
      Location:316 → 390
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:247 → 305
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      smart00323
      Location:669 → 1017
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13260
      Location:443 → 548
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:445 → 549
      PH; PH domain
      cl02569
      Location:684 → 1018
      RasGAP; Ras GTPase Activating Domain
      cl15255
      Location:136 → 230
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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