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    SMAD5 SMAD family member 5 [ Equus caballus (horse) ]

    Gene ID: 100033851, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SMAD5provided by VGNC
    Official Full Name
    SMAD family member 5provided by VGNC
    Primary source
    VGNC:VGNC:23314
    See related
    Ensembl:ENSECAG00000018506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD5 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 14 NC_009157.3 (39220508..39267047, complement)

    Chromosome 14 - NC_009157.3Genomic Context describing neighboring genes Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Neighboring gene uncharacterized LOC111767806 Neighboring gene transient receptor potential cation channel subfamily C member 7 Neighboring gene transforming growth factor beta induced Neighboring gene leukocyte cell derived chemotaxin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009157.3 Chromosome 14 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163888.1 → NP_001157360.1  mothers against decapentaplegic homolog 5

      See identical proteins and their annotated locations for NP_001157360.1

      Status: PROVISIONAL

      Source sequence(s)
      PJAA01000015
      UniProtKB/TrEMBL
      A0A9L0RWK2, F7A120
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009157.3 Reference EquCab3.0 Primary Assembly

      Range
      39220508..39267047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023616889.1 → XP_023472657.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/TrEMBL
      A0A9L0RWK2, F7A120
      Related
      ENSECAP00000016173.1, ENSECAT00000019737.4
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    2. XM_005599129.3 → XP_005599186.1  mothers against decapentaplegic homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_005599186.1

      UniProtKB/TrEMBL
      A0A9L0RWK2, F7A120
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    3. XM_023616890.1 → XP_023472658.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/TrEMBL
      A0A9L0RWK2, F7A120
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
    Nucleotide Protein
    Heading Accession and Version

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