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    ptk2b protein tyrosine kinase 2 beta [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 496459, updated on 4-Nov-2024

    Summary

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    Official Symbol
    ptk2bprovided by Xenbase
    Official Full Name
    protein tyrosine kinase 2 betaprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-489525
    See related
    Ensembl:ENSXETG00000017538 AllianceGenome:Xenbase:XB-GENE-489525
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    pkb; ptk; cakb; fak2; pyk2; cadtk; fadk2; raftk
    Summary
    Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within several processes, including positive regulation of cell population proliferation; protein phosphorylation; and signal complex assembly. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ptk2b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (153280819..153359412)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (146316198..146392502, complement)

    Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene angiopoietin-related protein 7 Neighboring gene stathmin 4 Neighboring gene cholinergic receptor, nicotinic alpha 2 Neighboring gene uncharacterized LOC100496183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine kinase 2-beta
    Names
    PTK2B protein tyrosine kinase 2 beta
    NP_001011049.1
    XP_012819490.1
    XP_012819491.1
    XP_031757526.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011049.1 → NP_001011049.1  protein-tyrosine kinase 2-beta

      See identical proteins and their annotated locations for NP_001011049.1

      Status: PROVISIONAL

      Source sequence(s)
      BC084174
      UniProtKB/TrEMBL
      A0A6I8SIX4, Q5XH98
      Conserved Domains (6) summary
      cd05056
      Location:256 → 525
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:265 → 517
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:7 → 103
      B41; Band 4.1 homologues
      cd13190
      Location:99 → 206
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:8 → 94
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:722 → 851
      Focal_AT; Focal adhesion targeting region

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      153280819..153359412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012964037.3 → XP_012819491.1  protein-tyrosine kinase 2-beta isoform X1

      See identical proteins and their annotated locations for XP_012819491.1

      UniProtKB/TrEMBL
      A0A6I8SIX4, A0A6I8SU60
      Related
      ENSXETP00000096642.1, ENSXETT00000091983.2
      Conserved Domains (5) summary
      cd05056
      Location:414 → 683
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:37 → 261
      B41; Band 4.1 homologues
      cd13190
      Location:257 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:880 → 1009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 133
      FERM_N_2; FERM N-terminal domain

    2. XM_012964036.3 → XP_012819490.1  protein-tyrosine kinase 2-beta isoform X1

      See identical proteins and their annotated locations for XP_012819490.1

      UniProtKB/TrEMBL
      A0A6I8SIX4, A0A6I8SU60
      Conserved Domains (5) summary
      cd05056
      Location:414 → 683
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:37 → 261
      B41; Band 4.1 homologues
      cd13190
      Location:257 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:880 → 1009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 133
      FERM_N_2; FERM N-terminal domain

    3. XM_031901666.1 → XP_031757526.1  protein-tyrosine kinase 2-beta isoform X1

      UniProtKB/TrEMBL
      A0A6I8SIX4, A0A6I8SU60
      Conserved Domains (5) summary
      cd05056
      Location:414 → 683
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:37 → 261
      B41; Band 4.1 homologues
      cd13190
      Location:257 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:880 → 1009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 133
      FERM_N_2; FERM N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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