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    FSD2 fibronectin type III and SPRY domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 123722, updated on 3-Apr-2024

    Summary

    Official Symbol
    FSD2provided by HGNC
    Official Full Name
    fibronectin type III and SPRY domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:18024
    See related
    Ensembl:ENSG00000186628 AllianceGenome:HGNC:18024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPRYD1
    Summary
    This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in heart (RPKM 7.7), prostate (RPKM 0.9) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    15q25.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (82755362..82806069, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (80619626..80670359, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83424114..83474821, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene epididymal protein pseudogene Neighboring gene actin gamma 1 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9965 Neighboring gene MPRA-validated peak2404 silencer Neighboring gene small Cajal body-specific RNA 15 Neighboring gene small nucleolar RNA host gene 21 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:83450989-83451154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6756 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:83501038-83502237 Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:83518553-83519328 Neighboring gene homer scaffold protein 2 Neighboring gene uncharacterized LOC105370928

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    fibronectin type III and SPRY domain-containing protein 2
    Names
    SPRY domain containing 1
    SPRY domain-containing protein 1
    minispryn

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007122.4NP_001007123.1  fibronectin type III and SPRY domain-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_001007123.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC105339, AK122875, AL833295
      Consensus CDS
      CCDS45332.1
      UniProtKB/Swiss-Prot
      A1L4K1, B3KVG1, B7ZM02
      UniProtKB/TrEMBL
      B7ZM05
      Related
      ENSP00000335651.8, ENST00000334574.12
      Conserved Domains (4) summary
      smart00060
      Location:372457
      FN3; Fibronectin type 3 domain
      cd00063
      Location:469561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:565740
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
      cl25602
      Location:188333
      DUF3552; Domain of unknown function (DUF3552)
    2. NM_001281805.2NP_001268734.1  fibronectin type III and SPRY domain-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001268734.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC105339, AL833295, BC144175, DA826684
      Consensus CDS
      CCDS61738.1
      UniProtKB/TrEMBL
      B7ZM05
      Conserved Domains (3) summary
      cd00063
      Location:424516
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:520695
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
      cl23765
      Location:222336
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. NM_001281806.2NP_001268735.1  fibronectin type III and SPRY domain-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001268735.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC105339, AL833295, BC144181, DA826684
      Consensus CDS
      CCDS61738.1
      UniProtKB/TrEMBL
      B7ZM05
      Related
      ENSP00000444078.1, ENST00000541889.1
      Conserved Domains (3) summary
      cd00063
      Location:424516
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:520695
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
      cl23765
      Location:222336
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      82755362..82806069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521235.4XP_011519537.1  fibronectin type III and SPRY domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      B7ZM05
      Conserved Domains (3) summary
      smart00060
      Location:295380
      FN3; Fibronectin type 3 domain
      cd00063
      Location:392484
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:488663
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
    2. XM_005272425.6XP_005272482.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005272482.1

      UniProtKB/Swiss-Prot
      A1L4K1, B3KVG1, B7ZM02
      UniProtKB/TrEMBL
      B7ZM05
      Conserved Domains (4) summary
      smart00060
      Location:372457
      FN3; Fibronectin type 3 domain
      cd00063
      Location:469561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:565740
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
      cl25602
      Location:188333
      DUF3552; Domain of unknown function (DUF3552)
    3. XM_024449844.2XP_024305612.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A1L4K1, B3KVG1, B7ZM02
      UniProtKB/TrEMBL
      B7ZM05
      Conserved Domains (4) summary
      smart00060
      Location:372457
      FN3; Fibronectin type 3 domain
      cd00063
      Location:469561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:565740
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
      cl25602
      Location:188333
      DUF3552; Domain of unknown function (DUF3552)
    4. XM_024449845.2XP_024305613.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A1L4K1, B3KVG1, B7ZM02
      UniProtKB/TrEMBL
      B7ZM05
      Conserved Domains (4) summary
      smart00060
      Location:372457
      FN3; Fibronectin type 3 domain
      cd00063
      Location:469561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd12899
      Location:565740
      SPRY_PRY_TRIM76_like; PRY/SPRY domain in tripartite motif-containing protein 76 (TRIM76)-like
      cl25602
      Location:188333
      DUF3552; Domain of unknown function (DUF3552)
    5. XM_047432156.1XP_047288112.1  fibronectin type III and SPRY domain-containing protein 2 isoform X3

    6. XM_017021924.3XP_016877413.1  fibronectin type III and SPRY domain-containing protein 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      80619626..80670359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377301.1XP_054233276.1  fibronectin type III and SPRY domain-containing protein 2 isoform X2

    2. XM_054377299.1XP_054233274.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

    3. XM_054377298.1XP_054233273.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

    4. XM_054377300.1XP_054233275.1  fibronectin type III and SPRY domain-containing protein 2 isoform X1

    5. XM_054377302.1XP_054233277.1  fibronectin type III and SPRY domain-containing protein 2 isoform X3

    6. XM_054377303.1XP_054233278.1  fibronectin type III and SPRY domain-containing protein 2 isoform X4