thbs3b thrombospondin 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: thbs3bprovided by ZNC
Official Full Name: thrombospondin 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-84
See related: Ensembl:ENSDARG00000012060 AllianceGenome:ZFIN:ZDB-GENE-060503-84
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-81h8.2
Summary: Predicted to enable calcium ion binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (24416184..24443644, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (24833857..24859440, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thrombospondin-3b

Names: Tsp-3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045214.1 → NP_001038679.1 thrombospondin-3b precursor

See identical proteins and their annotated locations for NP_001038679.1

Status: PROVISIONAL

Source sequence(s)

CR749746

UniProtKB/Swiss-Prot

Q1L8P7

Related

ENSDARP00000085258.5, ENSDART00000090825.6

Conserved Domains (8) summary

smart00179
Location:345 → 383

EGF_CA; Calcium-binding EGF-like domain

sd00001
Location:584 → 621

TSP3; TSP3 repeat_long [structural motif]

sd00002
Location:466 → 501

TSP3; TSP3 repeat_long [structural motif]

pfam02412
Location:526 → 560

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:715 → 912

TSP_C; Thrombospondin C-terminal region

cd16076
Location:229 → 268

TSPcc; coiled coil [structural motif]

cl13107
Location:226 → 268

TSPcc; Coiled coil region of thrombospondin

cl22861
Location:55 → 192

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

24416184..24443644 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170062.5 → XP_005170119.1 thrombospondin-3b isoform X1

UniProtKB/TrEMBL

A0A8M2BHE1

Conserved Domains (9) summary

smart00179
Location:368 → 406

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:315 → 350

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:607 → 644

TSP3; TSP3 repeat_long [structural motif]

sd00002
Location:489 → 524

TSP3; TSP3 repeat_long [structural motif]

pfam02412
Location:549 → 583

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:738 → 935

TSP_C; Thrombospondin C-terminal region

cd16076
Location:229 → 268

TSPcc; coiled coil [structural motif]

cl13107
Location:226 → 268

TSPcc; Coiled coil region of thrombospondin

cl22861
Location:55 → 192

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...