fbxw11b F-box and WD repeat domain containing 11b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbxw11bprovided by ZNC
Official Full Name: F-box and WD repeat domain containing 11bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2903
See related: Ensembl:ENSDARG00000017230 AllianceGenome:ZFIN:ZDB-GENE-040426-2903
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: btrc2; fbxw11a; zgc:63728; wu:fa12e12; wu:fb11f03
Summary: Predicted to enable protein dimerization activity. Acts upstream of or within sprouting angiogenesis. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; head mesenchyme; oral epithelium; pectoral fin; and retina. Orthologous to several human genes including FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (21444655..21470590)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (21487246..21513209)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fi49f03.y1 (e-PCR)
- UniSTS:197642

AA494784 (e-PCR)
- UniSTS:205353

fb11f03.x1 (e-PCR)
- UniSTS:202843

AA494784 (e-PCR)
- UniSTS:206973

fi31f01.x1 (e-PCR)
- UniSTS:197263

fa19e07.s1 (e-PCR)
- UniSTS:202448

fb83d07.x1 (e-PCR)
- UniSTS:203490

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box and WD repeat domain-containing 11-B

Names: F-box and WD-40 domain protein 11b; F-box/WD repeat-containing protein 11b; fbxw11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213504.2 → NP_998669.2 F-box and WD repeat domain-containing 11-B

Status: PROVISIONAL

Source sequence(s)

BC056809

UniProtKB/Swiss-Prot

A0A2R8RWN9, Q6PGW4

UniProtKB/TrEMBL

F6PB05

Related

ENSDARP00000017497.7, ENSDART00000019252.8

Conserved Domains (5) summary

COG2319
Location:216 → 510

WD40; WD40 repeat [General function prediction only]

cd00200
Location:229 → 507

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:67 → 105

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:109 → 156

F-box-like; F-box-like

sd00039
Location:232 → 267

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

21444655..21470590

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005155294.5 → XP_005155351.1 F-box and WD repeat domain-containing 11-B isoform X1

UniProtKB/Swiss-Prot

A0A2R8RWN9, Q6PGW4

UniProtKB/TrEMBL

A0A8M2B267, E9QCK5

Related

ENSDARP00000117181.1, ENSDART00000140113.3

Conserved Domains (5) summary

COG2319
Location:209 → 503

WD40; WD40 repeat [General function prediction only]

cd00200
Location:222 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:60 → 98

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:102 → 149

F-box-like; F-box-like

sd00039
Location:225 → 260

7WD40; WD40 repeat [structural motif]