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    zfp91 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase [ Danio rerio (zebrafish) ]

    Gene ID: 555616, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zfp91provided by ZNC
    Official Full Name
    ZFP91 zinc finger protein, atypical E3 ubiquitin ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-11
    See related
    Ensembl:ENSDARG00000079631 AllianceGenome:ZFIN:ZDB-GENE-090313-11
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-113e8.10
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See zfp91 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (40111539..40132846, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (39398494..39414786, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:dkey-117m1.4 Neighboring gene si:ch211-113e8.11 Neighboring gene ciliary neurotrophic factor Neighboring gene uncharacterized LOC137495637 Neighboring gene zgc:152658 Neighboring gene zgc:194443

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 91 homolog; E3 ubiquitin-protein ligase ZFP91

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      40111539..40132846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476803.2 → XP_021332478.1  E3 ubiquitin-protein ligase ZFP91 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PZJ4
      Conserved Domains (4) summary
      sd00017
      Location:313 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:367 → 388
      zf-C2H2; Zinc finger, C2H2 type
      pfam15909
      Location:279 → 356
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25764
      Location:552 → 637
      PAT1; Topoisomerase II-associated protein PAT1

    2. XM_005160009.5 → XP_005160066.1  E3 ubiquitin-protein ligase ZFP91 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B774
      Conserved Domains (3) summary
      sd00017
      Location:344 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:383 → 408
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:310 → 387
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_068221524.1 → XP_068077625.1  E3 ubiquitin-protein ligase ZFP91 isoform X6

    4. XM_005160008.5 → XP_005160065.1  E3 ubiquitin-protein ligase ZFP91 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B6P1
      Conserved Domains (4) summary
      sd00017
      Location:371 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:410 → 435
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:337 → 414
      zf-C2H2_8; C2H2-type zinc ribbon
      cl22451
      Location:165 → 303
      ASF1_hist_chap; ASF1 like histone chaperone

    5. XM_005160007.5 → XP_005160064.1  E3 ubiquitin-protein ligase ZFP91 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B6T6
      Conserved Domains (3) summary
      sd00017
      Location:401 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:440 → 465
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:367 → 444
      zf-C2H2_8; C2H2-type zinc ribbon

    6. XM_678183.10 → XP_683275.2  E3 ubiquitin-protein ligase ZFP91 isoform X1

      UniProtKB/TrEMBL
      A0A8N7UVJ7, F6NIE2
      Related
      ENSDARP00000115246.2, ENSDART00000135647.4
      Conserved Domains (3) summary
      sd00017
      Location:402 → 421
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:441 → 466
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:368 → 445
      zf-C2H2_8; C2H2-type zinc ribbon

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394500.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      101007..118780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471227.2 → XP_021326902.1  E3 ubiquitin-protein ligase ZFP91 isoform X5

      UniProtKB/TrEMBL
      A0A8M9P807
      Conserved Domains (4) summary
      sd00017
      Location:313 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:367 → 388
      zf-C2H2; Zinc finger, C2H2 type
      pfam15909
      Location:279 → 356
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25764
      Location:552 → 637
      PAT1; Topoisomerase II-associated protein PAT1

    2. XM_021471226.2 → XP_021326901.1  E3 ubiquitin-protein ligase ZFP91 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PX97
      Conserved Domains (4) summary
      sd00017
      Location:344 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:398 → 419
      zf-C2H2; Zinc finger, C2H2 type
      pfam15909
      Location:310 → 387
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25764
      Location:583 → 668
      PAT1; Topoisomerase II-associated protein PAT1

    3. XM_021471225.2 → XP_021326900.1  E3 ubiquitin-protein ligase ZFP91 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q0L6
      Conserved Domains (4) summary
      sd00017
      Location:371 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:425 → 446
      zf-C2H2; Zinc finger, C2H2 type
      pfam15909
      Location:337 → 414
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25716
      Location:602 → 685
      Amelogenin

    4. XM_021471224.2 → XP_021326899.1  E3 ubiquitin-protein ligase ZFP91 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PPW7
      Conserved Domains (4) summary
      sd00017
      Location:401 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:455 → 476
      zf-C2H2; Zinc finger, C2H2 type
      pfam15909
      Location:367 → 444
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25716
      Location:632 → 715
      Amelogenin

    5. XM_021471223.2 → XP_021326898.1  E3 ubiquitin-protein ligase ZFP91 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PIW3
      Conserved Domains (4) summary
      sd00017
      Location:402 → 421
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:456 → 477
      zf-C2H2; Zinc finger, C2H2 type
      pfam15909
      Location:368 → 445
      zf-C2H2_8; C2H2-type zinc ribbon
      cl25716
      Location:633 → 716
      Amelogenin
    Nucleotide Protein
    Heading Accession and Version

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