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    ERVK-21 endogenous retrovirus group K member 21, envelope [ Homo sapiens (human) ]

    Gene ID: 100616103, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERVK-21provided by HGNC
    Official Full Name
    endogenous retrovirus group K member 21, envelopeprovided by HGNC
    Primary source
    HGNC:HGNC:39035
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; c12_A; envK1; Protease; Endo-Rev2; Proteinase
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    Genomic context

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    Location:
    12q14.1

    Bibliography

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    Related articles in PubMed

    1. Quantitation of HERV-K env gene expression and splicing in human breast cancer. Wang-Johanning F, et al. Oncogene, 2003 Mar 13. PMID 12629516
    2. Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins. de Parseval N, et al. J Virol, 2003 Oct. PMID 12970426, Free PMC Article
    3. Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project. Flockerzi A, et al. BMC Genomics, 2008 Jul 29. PMID 18664271, Free PMC Article
    4. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Blaise S, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14557543, Free PMC Article
    5. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • Endogenous retrovirus group K member 21 Gag polyprotein
    • Endogenous retrovirus group K member 21 Pro protein
    • Endogenous retrovirus group K member 21 Rec protein
    • Envelope polyprotein
    • Gag polyprotein
    • HERV-K_12q14.1 provirus Rec protein
    • HERV-K_12q14.1 provirus ancestral Env polyprotein
    • HERV-K_12q14.1 provirus ancestral Gag polyprotein
    • HERV-K_12q14.1 provirus ancestral Pro protein
    • endogenous retrovirus group K, member 21

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in syncytium formation by plasma membrane fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61565.1 GenPept UniProtKB/Swiss-Prot:P61565
    P61571.1 GenPept UniProtKB/Swiss-Prot:P61571
    P62683.2 GenPept UniProtKB/Swiss-Prot:P62683
    P63119.1 GenPept UniProtKB/Swiss-Prot:P63119

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