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    tyk2 tyrosine kinase 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100489432, updated on 4-Nov-2024

    Summary

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    Official Symbol
    tyk2provided by Xenbase
    Official Full Name
    tyrosine kinase 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-993652
    See related
    Ensembl:ENSXETG00000011623 AllianceGenome:Xenbase:XB-GENE-993652
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within cytokine-mediated signaling pathway; intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tyk2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (137608908..137647960, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (127065281..127102848, complement)

    Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene zinc finger GATA like protein 1 Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene cell division cycle 37 Neighboring gene phosphodiesterase 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    non-receptor tyrosine-protein kinase TYK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      137608908..137647960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004918815.4 → XP_004918872.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      UniProtKB/TrEMBL
      A0A8J0R3W8
      Conserved Domains (7) summary
      smart00219
      Location:888 → 1160
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:25 → 277
      B41; Band 4.1 homologues
      cd05076
      Location:587 → 859
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:883 → 1165
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:592 → 858
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:432 → 528
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:273 → 432
      PH-like; Pleckstrin homology-like domain

    2. XM_004918814.4 → XP_004918871.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      See identical proteins and their annotated locations for XP_004918871.1

      UniProtKB/TrEMBL
      A0A6I8QQ90
      Conserved Domains (6) summary
      cd05076
      Location:588 → 860
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:884 → 1166
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam18377
      Location:139 → 268
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:25 → 115
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:432 → 528
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:273 → 432
      PH-like; Pleckstrin homology-like domain

    3. XM_002939674.5 → XP_002939720.2  non-receptor tyrosine-protein kinase TYK2 isoform X1

      See identical proteins and their annotated locations for XP_002939720.2

      UniProtKB/TrEMBL
      A0A6I8QQ90
      Related
      ENSXETP00000071450.2, ENSXETT00000073688.2
      Conserved Domains (6) summary
      cd05076
      Location:588 → 860
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:884 → 1166
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam18377
      Location:139 → 268
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:25 → 115
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:432 → 528
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:273 → 432
      PH-like; Pleckstrin homology-like domain

    4. XM_012953004.3 → XP_012808458.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

      See identical proteins and their annotated locations for XP_012808458.1

      UniProtKB/TrEMBL
      A0A6I8QQ90
      Conserved Domains (6) summary
      cd05076
      Location:588 → 860
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:884 → 1166
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam18377
      Location:139 → 268
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:25 → 115
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:432 → 528
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:273 → 432
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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