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    ARHGAP10 Rho GTPase activating protein 10 [ Homo sapiens (human) ]

    Gene ID: 79658, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARHGAP10provided by HGNC
    Official Full Name
    Rho GTPase activating protein 10provided by HGNC
    Primary source
    HGNC:HGNC:26099
    See related
    Ensembl:ENSG00000071205 MIM:609746; AllianceGenome:HGNC:26099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRAF2; PSGAP; PS-GAP
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Located in cytosol and endosome membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 17.3), ovary (RPKM 10.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP10 in Genome Data Viewer
    Location:
    4q31.23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (147732088..148072776)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (151056194..151396701)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (148653239..148993927)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22002 Neighboring gene NANOG hESC enhancer GRCh37_chr4:148576650-148577308 Neighboring gene transmembrane protein 184C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:148619575-148620075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22003 Neighboring gene protein arginine methyltransferase 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:148652850-148653742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:148653743-148654635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22005 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:148659209-148659934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22007 Neighboring gene RNA, 5S ribosomal pseudogene 165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:148742253-148742753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:148741752-148742252 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:148752558-148753757 Neighboring gene microRNA 4799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22011 Neighboring gene RNA, 7SL, cytoplasmic 254, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:148787949-148788626 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:148788627-148789303 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:148854887-148855386 Neighboring gene ret finger protein like 4A pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22012 Neighboring gene VISTA enhancer hs2100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:149011589-149012238 Neighboring gene nuclear receptor subfamily 3 group C member 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:149113429-149114628 Neighboring gene uncharacterized LOC102724672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:149244835-149245396 Neighboring gene MPRA-validated peak5133 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15746 Neighboring gene uncharacterized LOC124900798

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide association study of prognosis in breast cancer. Azzato EM, et al. Cancer Epidemiol Biomarkers Prev, 2010 Apr. PMID 20332263, Free PMC Article
    2. ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells. Luo N, et al. Cell Death Dis, 2016 Mar 24. PMID 27010858, Free PMC Article
    3. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Sekiguchi M, et al. Transl Psychiatry, 2020 Jul 22. PMID 32699248, Free PMC Article
    4. CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression. Luo N, et al. Biochem Biophys Res Commun, 2019 Oct 20. PMID 31445707
    5. miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10. Wang Z, et al. Mol Med Rep, 2020 Feb. PMID 31789419, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.
      Title: ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.
    2. GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.
      Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.
    3. miR3373p inhibits gastric tumor metastasis by targeting ARHGAP10.
      Title: miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10.
    4. These findings suggest that CXCL12/CXCR4 promotes ovarian cancer cell invasion by suppressing ARHGAP10 expression, which is mediated by VEGF/VEGFR2 signaling.
      Title: CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.
    5. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways.
      Title: ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)).
      Title: A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.
    8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study of prognosis in breast cancer.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutation of ARHGAP9 in patients with coronary spastic angina.
    10. PS-GAP is a novel regulator of caspase-activated PAK-2
      Title: Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20896, FLJ41791

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 10
    Names
    GTPase regulator associated with focal adhesion kinase 2
    graf-related protein 2
    rho-type GTPase-activating protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024605.4 → NP_078881.3  rho GTPase-activating protein 10

      See identical proteins and their annotated locations for NP_078881.3

      Status: VALIDATED

      Source sequence(s)
      AC093835, AK123785, BC011920
      Consensus CDS
      CCDS34075.1
      UniProtKB/Swiss-Prot
      A1A4S6, A1L0S5, Q2VPC4, Q2VPC5, Q96EV3, Q96S75
      UniProtKB/TrEMBL
      A0A2X0SFB3
      Related
      ENSP00000336923.3, ENST00000336498.8
      Conserved Domains (4) summary
      cd07635
      Location:19 → 225
      BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
      cd12065
      Location:732 → 785
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367 → 569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 374
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      147732088..148072776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263215.4 → XP_005263272.1  rho GTPase-activating protein 10 isoform X1

      Conserved Domains (5) summary
      cd12065
      Location:681 → 734
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367 → 569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 374
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:269 → 367
      PH; PH domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_047416160.1 → XP_047272116.1  rho GTPase-activating protein 10 isoform X3

    3. XM_047416161.1 → XP_047272117.1  rho GTPase-activating protein 10 isoform X3

    4. XM_047416158.1 → XP_047272114.1  rho GTPase-activating protein 10 isoform X2

    RNA

    1. XR_001741324.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      151056194..151396701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350824.1 → XP_054206799.1  rho GTPase-activating protein 10 isoform X1

    2. XM_054350826.1 → XP_054206801.1  rho GTPase-activating protein 10 isoform X3

    3. XM_054350825.1 → XP_054206800.1  rho GTPase-activating protein 10 isoform X2

    RNA

    1. XR_008487029.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A4S6.1 GenPept UniProtKB/Swiss-Prot:A1A4S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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