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    IRX4 iroquois homeobox 4 [ Gallus gallus (chicken) ]

    Gene ID: 373974, updated on 17-Aug-2024

    Summary

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    Symbol
    IRX4provided by CGNC
    Full Name
    iroquois homeobox 4provided by CGNC
    Primary source
    CGNC:15827
    See related
    Ensembl:ENSGALG00010007564
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See IRX4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (85661757..85670393, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (85738080..85746718, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109624 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6 Neighboring gene uncharacterized LOC121109625 Neighboring gene uncharacterized LOC107052648 Neighboring gene uncharacterized LOC112531818 Neighboring gene uncharacterized LOC101747569

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of chamber-specific gene expression in the developing heart by Irx4. Bao ZZ, et al. Science, 1999 Feb 19. PMID 10024241
    2. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. Ogura K, et al. Cytogenet Cell Genet, 2001. PMID 11435706
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iroquois-class homeodomain protein IRX-4
    Names
    iroquois homeobox protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001744.2 → NP_001001744.1  iroquois-class homeodomain protein IRX-4

      See identical proteins and their annotated locations for NP_001001744.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000041
      UniProtKB/Swiss-Prot
      Q9YGS0
      Related
      ENSGALP00010009914.1, ENSGALT00010018008.1
      Conserved Domains (3) summary
      smart00548
      Location:347 → 363
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      COG5576
      Location:144 → 245
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam05920
      Location:159 → 198
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      85661757..85670393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046917125.1 → XP_046773081.1  iroquois-class homeodomain protein IRX-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9YGS0

    2. XM_015282323.4 → XP_015137809.1  iroquois-class homeodomain protein IRX-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9YGS0
      Conserved Domains (3) summary
      smart00548
      Location:347 → 363
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      COG5576
      Location:144 → 245
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam05920
      Location:159 → 198
      Homeobox_KN; Homeobox KN domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      85738080..85746718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910179.1 → XP_046766135.1  iroquois-class homeodomain protein IRX-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9YGS0

    2. XM_046910178.1 → XP_046766134.1  iroquois-class homeodomain protein IRX-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9YGS0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YGS0.1 GenPept UniProtKB/Swiss-Prot:Q9YGS0

    Gene LinkOut

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    Research Materials