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    LYG1 lysozyme g1 [ Homo sapiens (human) ]

    Gene ID: 129530, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LYG1provided by HGNC
    Official Full Name
    lysozyme g1provided by HGNC
    Primary source
    HGNC:HGNC:27014
    See related
    Ensembl:ENSG00000144214 AllianceGenome:HGNC:27014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYGA1; SALW1939
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 2.5), testis (RPKM 0.7) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LYG1 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (99284238..99304775, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99742858..99763389, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99900701..99921238, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99797856-99798028 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme g2 Neighboring gene uncharacterized LOC107985923 Neighboring gene thioredoxin domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99952564-99953104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99953733-99954234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99954235-99954734 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene REV1 DNA directed polymerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of vertebrate goose-type lysozyme genes. Irwin DM, et al. J Mol Evol, 2003 Feb. PMID 12574869
    2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article
    3. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme g-like protein 1
    Names
    lysozyme G-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371380.1 → NP_001358309.1  lysozyme g-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC079447
      Consensus CDS
      CCDS2043.1
      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2
      Related
      ENSP00000386923.1, ENST00000409448.1
      Conserved Domains (1) summary
      cd16888
      Location:38 → 194
      lyz_G-like_1; lysozyme G-like protein 1

    2. NM_174898.3 → NP_777558.1  lysozyme g-like protein 1 precursor

      See identical proteins and their annotated locations for NP_777558.1

      Status: VALIDATED

      Source sequence(s)
      AC079447, BC029126, BG194505
      Consensus CDS
      CCDS2043.1
      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2
      Related
      ENSP00000311320.4, ENST00000308528.9
      Conserved Domains (1) summary
      cd16888
      Location:38 → 194
      lyz_G-like_1; lysozyme G-like protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      99284238..99304775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443274.1 → XP_047299230.1  lysozyme g-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2

    2. XM_047443275.1 → XP_047299231.1  lysozyme g-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2

    3. XM_011510580.2 → XP_011508882.1  lysozyme g-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011508882.1

      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2
      Conserved Domains (1) summary
      cd16888
      Location:38 → 194
      lyz_G-like_1; lysozyme G-like protein 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      99742858..99763389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340478.1 → XP_054196453.1  lysozyme g-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2

    2. XM_054340477.1 → XP_054196452.1  lysozyme g-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2

    3. XM_054340479.1 → XP_054196454.1  lysozyme g-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53RV9, Q8N1E2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N1E2.1 GenPept UniProtKB/Swiss-Prot:Q8N1E2

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