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    Gat GABA transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43805, updated on 4-Jul-2024

    Summary

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    Official Symbol
    Gatprovided by FlyBase
    Official Full Name
    GABA transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039915
    Locus tag
    Dmel_CG1732
    See related
    AllianceGenome:FB:FBgn0039915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0149848.11; CG1732; CG1732a; dGAT; Dmel\CG1732; DmGAT; gat; GAT
    Summary
    Predicted to enable gamma-aminobutyric acid:sodium symporter activity. Involved in cellular response to mechanical stimulus. Located in glial cell projection and plasma membrane. Is expressed in anterior-posterior subdivision of organism; central nervous system; and embryonic/larval nervous system. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gat in Genome Data Viewer
    Location:
    102D1-102D1; 4-0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (629691..635350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (650317..655976)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene maverick Neighboring gene mir-954 stem loop Neighboring gene pseudo Neighboring gene Eye-enriched kainate receptor Neighboring gene gawky

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders. Fischer FP, et al. Front Mol Biosci, 2022. PMID 35295842, Free PMC Article
    2. GABA transporters in Drosophila melanogaster: molecular cloning, behavior, and physiology. Neckameyer WS, et al. Invert Neurosci, 1998 Mar. PMID 10212397
    3. Microbiota alterations in proline metabolism impact depression. Mayneris-Perxachs J, et al. Cell Metab, 2022 May 3. PMID 35508109
    4. A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila. Nyberg KG, et al. Fly (Austin), 2020 Mar-Dec. PMID 33016195, Free PMC Article
    5. Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons. Chaturvedi R, et al. Curr Biol, 2022 May 9. PMID 35303417, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 630665-630838 mobile_element_type = transposon:INE-1{}1920

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-aminobutyric acid:sodium:chloride symporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GABA transporter
    Names
    CG1732-PA
    CG1732-PB
    Gat-PA
    Gat-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      629691..635350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143673.3 → NP_651930.2  GABA transporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651930.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NND1, Q7YU42, Q9V4E7
      Related
      FBpp0088910
      Conserved Domains (1) summary
      cd11496
      Location:58 → 611
      SLC6sbd-TauT-like; Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain

    2. NM_166779.4 → NP_726594.2  GABA transporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726594.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMC1
      Related
      FBpp0088909
      Conserved Domains (1) summary
      cl00456
      Location:58 → 499
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMC1 Q8IMC1
    Q9V4E7 Q9V4E7

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