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    Spn77Ba Serpin 77Ba [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40234, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spn77Baprovided by FlyBase
    Official Full Name
    Serpin 77Baprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262057
    Locus tag
    Dmel_CG6680
    See related
    AllianceGenome:FB:FBgn0262057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6680; Dmel\CG6680; l(3)77ABi; Q0E8C8_DROME; spn77Ba
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of melanization defense response. Located in extracellular space. Is expressed in adult head; embryonic/larval gut; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Spn77Ba in Genome Data Viewer
    Location:
    77B3-77B4; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20317190..20320116)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20310290..20313216)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene polo Neighboring gene alpha Soluble NSF attachment protein Neighboring gene antisense RNA:CR43875 Neighboring gene Serpin 77Bb Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. An C, et al. PLoS One, 2013. PMID 24260243, Free PMC Article
    2. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416
    3. Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Scherfer C, et al. Dev Biol, 2008 Nov 15. PMID 18801354
    4. A serpin that regulates immune melanization in the respiratory system of Drosophila. Tang H, et al. Dev Cell, 2008 Oct. PMID 18854145, Free PMC Article
    5. Expression profiling of Drosophila imaginal discs. Klebes A, et al. Genome Biol, 2002 Jul 24. PMID 12186645, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 77Ba
    Names
    CG6680-PA
    CG6680-PB
    CG6680-PC
    Spn77Ba-PA
    Spn77Ba-PB
    Spn77Ba-PC
    lethal (3) 77ABi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20317190..20320116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300199.1 → NP_001287128.1  serpin 77Ba, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8C8, Q8IGD7, Q95SG7
      Conserved Domains (1) summary
      cd00172
      Location:75 → 444
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_140948.4 → NP_649205.3  serpin 77Ba, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649205.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8C8, Q8IGD7, Q95SG7
      Related
      FBpp0074610
      Conserved Domains (1) summary
      cd00172
      Location:75 → 444
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    3. NM_168844.3 → NP_730512.2  serpin 77Ba, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730512.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8C8, Q8IGD7, Q95SG7
      Related
      FBpp0074611
      Conserved Domains (1) summary
      cd00172
      Location:75 → 444
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8C8.1 Q0E8C8

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