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    amdhd2 amidohydrolase domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 402981, updated on 2-Nov-2024

    Summary

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    Official Symbol
    amdhd2provided by ZNC
    Official Full Name
    amidohydrolase domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1871
    See related
    Ensembl:ENSDARG00000100376 AllianceGenome:ZFIN:ZDB-GENE-040426-1871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77775
    Summary
    Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process. Predicted to act upstream of or within N-acetylglucosamine metabolic process. Is expressed in blood vessel; immature eye; neural crest; retina; and yolk syncytial layer. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See amdhd2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (13525522..13546359, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (13375410..13396290, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 19 Neighboring gene jumonji domain containing 8 Neighboring gene uncharacterized LOC108182805 Neighboring gene noggin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Zhang P, et al. Cell Res, 2015 Oct. PMID 26358189, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77775

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acetylgalactosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylglucosamine-6-phosphate deacetylase
    Names
    amidohydrolase domain-containing protein 2
    glcNAc 6-P deacetylase
    putative N-acetylglucosamine-6-phosphate deacetylase
    NP_991244.1
    XP_005163800.1
    XP_021325611.2
    XP_068072395.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205681.1 → NP_991244.1  N-acetylglucosamine-6-phosphate deacetylase

      See identical proteins and their annotated locations for NP_991244.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065449
      UniProtKB/Swiss-Prot
      Q6P0U0
      UniProtKB/TrEMBL
      A0A8M9P5F6
      Related
      ENSDARP00000133871.1, ENSDART00000159647.2
      Conserved Domains (1) summary
      cd00854
      Location:13 → 398
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      13525522..13546359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163743.5 → XP_005163800.1  N-acetylglucosamine-6-phosphate deacetylase isoform X2

      See identical proteins and their annotated locations for XP_005163800.1

      UniProtKB/Swiss-Prot
      Q6P0U0
      UniProtKB/TrEMBL
      A0A8M9P5F6
      Conserved Domains (1) summary
      cd00854
      Location:13 → 398
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

    2. XM_068216294.1 → XP_068072395.1  N-acetylglucosamine-6-phosphate deacetylase isoform X2

    3. XM_021469936.2 → XP_021325611.2  N-acetylglucosamine-6-phosphate deacetylase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0U0.1 GenPept UniProtKB/Swiss-Prot:Q6P0U0

    Gene LinkOut

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