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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_009262.1 RefSeqGene
- Range
-
4998..19891
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_554
mRNA and Protein(s)
-
NM_000131.4 → NP_000122.1 coagulation factor VII isoform a preproprotein
See identical proteins and their annotated locations for NP_000122.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AI076552, AK310779, AL137002, M13232
- Consensus CDS
-
CCDS9528.1
- UniProtKB/Swiss-Prot
- B0YJC8, P08709, Q14339, Q5JVF1, Q5JVF2, Q9UD52, Q9UD53, Q9UD54
- UniProtKB/TrEMBL
-
B4DPM2
- Related
- ENSP00000364731.3, ENST00000375581.3
- Conserved Domains (5) summary
-
- smart00020
Location:212 → 446
- Tryp_SPc; Trypsin-like serine protease
- smart00069
Location:42 → 104
- GLA; Domain containing Gla (gamma-carboxyglutamate) residues
- cd00054
Location:106 → 142
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
- cd00190
Location:213 → 449
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam14670
Location:151 → 187
- FXa_inhibition; Coagulation Factor Xa inhibitory site
-
NM_001267554.2 → NP_001254483.1 coagulation factor VII isoform c precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks three consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
- Source sequence(s)
-
AI076552, AK298404, AL137002
- Consensus CDS
-
CCDS73602.1
- UniProtKB/TrEMBL
- B4DPM2, F5H8B0
- Related
- ENSP00000442051.2, ENST00000541084.5
- Conserved Domains (4) summary
-
- smart00020
Location:128 → 362
- Tryp_SPc; Trypsin-like serine protease
- cd00054
Location:22 → 58
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
- cd00190
Location:129 → 365
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam14670
Location:67 → 103
- FXa_inhibition; Coagulation Factor Xa inhibitory site
-
NM_019616.4 → NP_062562.1 coagulation factor VII isoform b precursor
See identical proteins and their annotated locations for NP_062562.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
- Source sequence(s)
-
AI076552, AK310779, AL137002, BC130468
- Consensus CDS
-
CCDS9529.1
- UniProtKB/TrEMBL
-
B4DPM2
- Related
- ENSP00000329546.4, ENST00000346342.8
- Conserved Domains (5) summary
-
- smart00020
Location:190 → 424
- Tryp_SPc; Trypsin-like serine protease
- smart00069
Location:21 → 82
- GLA; Domain containing Gla (gamma-carboxyglutamate) residues
- cd00054
Location:84 → 120
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
- cd00190
Location:191 → 427
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- pfam14670
Location:129 → 165
- FXa_inhibition; Coagulation Factor Xa inhibitory site
RNA
-
NR_051961.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks two internal exons and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AI076552, AK310779, AK311682, AL137002