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    C4BPA complement component 4 binding protein alpha [ Homo sapiens (human) ]

    Gene ID: 722, updated on 28-Oct-2024

    Summary

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    Official Symbol
    C4BPAprovided by HGNC
    Official Full Name
    complement component 4 binding protein alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1325
    See related
    Ensembl:ENSG00000123838 MIM:120830; AllianceGenome:HGNC:1325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRP; C4BP
    Summary
    This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 372.5) and lung (RPKM 75.1) See more
    Orthologs
    all
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    Genomic context

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    See C4BPA in Genome Data Viewer
    Location:
    1q32.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (207104233..207144972)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206369472..206410221)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207277578..207318317)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207224117-207224687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207225911-207226550 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:207240869-207241100 Neighboring gene YOD1 deubiquitinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2439 Neighboring gene complement component 4 binding protein beta Neighboring gene uncharacterized LOC107985251 Neighboring gene Sharpr-MPRA regulatory region 9788 Neighboring gene C4BPA pseudogene 1 Neighboring gene C4BPA pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity. Blom AM, et al. J Immunol, 2008 May 1. PMID 18424762
    2. [The early C4d urinary excretion and long-term kidney graft survival in patients treated with tacrolimus and mycophenolate mophetil]. Zwiech R. Pol Merkur Lekarski, 2014 Mar. PMID 24779215
    3. Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b. Ho DK, et al. Eur J Immunol, 2014 Mar. PMID 24760758
    4. Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss. Mohlin FC, et al. Eur J Immunol, 2013 Jun. PMID 23508668, Free PMC Article
    5. Arranged sevenfold: structural insights into the C-terminal oligomerization domain of human C4b-binding protein. Hofmeyer T, et al. J Mol Biol, 2013 Apr 26. PMID 23274142

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Higher-order structure and proteoforms of co-occurring C4b-binding protein assemblies in human serum.
      Title: Higher-order structure and proteoforms of co-occurring C4b-binding protein assemblies in human serum.
    2. The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPalpha as a Biomarker to Predict Clopidogrel Resistance.
      Title: The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance.
    3. Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein.
      Title: Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein.
    4. Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA.
      Title: Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA.
    5. The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.
      Title: The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity.
    6. Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma.
      Title: Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma.
    7. C4b-binding protein alpha-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer.
      Title: C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer.
    8. Observation of Complement Protein Gene Expression Before and After Surgery in Opioid-Consuming and Opioid-Naive Patients.
      Title: Observation of Complement Protein Gene Expression Before and After Surgery in Opioid-Consuming and Opioid-Naive Patients.
    9. Fetal lung C4BPA induces p100 processing in human placenta.
      Title: Fetal lung C4BPA induces p100 processing in human placenta.
    10. The authors conclude that Streptococcus pneumoniae PspA and PspC help the pneumococcus to evade complement attack by binding C4BP and so inactivating C4b.
      Title: The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of opsonization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to symbiotic bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C4b-binding protein alpha chain
    Names
    proline-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029579.1 RefSeqGene

      Range
      4972..45711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_547

    mRNA and Protein(s)

    1. NM_000715.4 → NP_000706.1  C4b-binding protein alpha chain precursor

      See identical proteins and their annotated locations for NP_000706.1

      Status: REVIEWED

      Source sequence(s)
      AL445493, BC022312, BQ019292
      Consensus CDS
      CCDS1477.1
      UniProtKB/Swiss-Prot
      P04003, Q5VVQ8
      UniProtKB/TrEMBL
      B4E1E1
      Related
      ENSP00000356037.3, ENST00000367070.8
      Conserved Domains (4) summary
      cd00033
      Location:175 → 235
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 422
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:298 → 538
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:484 → 538
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      207104233..207144972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273252.5 → XP_005273309.1  C4b-binding protein alpha chain isoform X1

      See identical proteins and their annotated locations for XP_005273309.1

      UniProtKB/Swiss-Prot
      P04003, Q5VVQ8
      UniProtKB/TrEMBL
      B4E1E1
      Conserved Domains (4) summary
      cd00033
      Location:175 → 235
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 422
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:298 → 538
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:484 → 538
      Sushi; Sushi repeat (SCR repeat)

    2. XM_005273251.3 → XP_005273308.1  C4b-binding protein alpha chain isoform X1

      See identical proteins and their annotated locations for XP_005273308.1

      UniProtKB/Swiss-Prot
      P04003, Q5VVQ8
      UniProtKB/TrEMBL
      B4E1E1
      Conserved Domains (4) summary
      cd00033
      Location:175 → 235
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:365 → 422
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:298 → 538
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:484 → 538
      Sushi; Sushi repeat (SCR repeat)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206369472..206410221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338582.1 → XP_054194557.1  C4b-binding protein alpha chain isoform X1

    2. XM_054338581.1 → XP_054194556.1  C4b-binding protein alpha chain isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04003.2 GenPept UniProtKB/Swiss-Prot:P04003

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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