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    PRL-1 PRL-1 phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34952, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PRL-1provided by FlyBase
    Official Full Name
    PRL-1 phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024734
    Locus tag
    Dmel_CG4993
    See related
    AllianceGenome:FB:FBgn0024734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE40268; BG:DS07473.3; CG4993; Dmel\CG4993; dPRL-1; PRL; prl-1; Prl-1; PrL-1; prl1; PRL1
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in cellular response to carbon dioxide and negative regulation of BMP signaling pathway. Located in cytoplasm and plasma membrane. Is expressed in several structures, including adult heart; amnioserosa; anterior-posterior subdivision of organism; embryonic/larval midgut primordium; and imaginal disc. Orthologous to several human genes including PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See PRL-1 in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16245835..16257606, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16245835..16257606, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ca[2+] channel Muscle-specific alpha2/delta subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Endonuclease G inhibitor Neighboring gene twine Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatase of Regenerating Liver-1 Regulates Wing Vein Formation through TGF-β Pathway in Drosophila melanogaster. Zheng H, et al. Front Biosci (Landmark Ed), 2022 Jun 1. PMID 35748252
    2. Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver. Fakih R, et al. J Biol Chem, 2023 Apr. PMID 36822330, Free PMC Article
    3. Drosophila Phosphatase of Regenerating Liver Is Critical for Photoreceptor Cell Polarity and Survival during Retinal Development. Chen SF, et al. Int J Mol Sci, 2023 Jul 15. PMID 37511262, Free PMC Article
    4. Drosophila PRL-1 is a growth inhibitor that counteracts the function of the Src oncogene. Pagarigan KT, et al. PLoS One, 2013. PMID 23577193, Free PMC Article
    5. Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. Lin MD, et al. BMC Dev Biol, 2013 May 4. PMID 23641863, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.
      Title: Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.
    2. compartmentalized restriction of Prl-1 serves as a specificity factor for the subcellular control of axonal synaptogenesis.
      Title: Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains.
    3. PRL binds to other membrane-localized proteins that are effectors of Src or to Src itself
      Title: Drosophila PRL-1 is a growth inhibitor that counteracts the function of the Src oncogene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to carbon dioxide IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PRL-1 phosphatase
    Names
    CG4993-PA
    CG4993-PB
    CG4993-PC
    CG4993-PD
    PRL-1-PA
    PRL-1-PB
    PRL-1-PC
    PRL-1-PD
    NP_001260487.1
    NP_001260488.1
    NP_609780.1
    NP_723956.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16245835..16257606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135936.3 → NP_609780.1  PRL-1 phosphatase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61722, Q95VY8
      UniProtKB/TrEMBL
      Q7KPK2
      Related
      FBpp0080413
      Conserved Domains (1) summary
      cd14500
      Location:10 → 163
      PTP-IVa; protein tyrosine phosphatase type IVA family

    2. NM_001273559.1 → NP_001260488.1  PRL-1 phosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61722, Q95VY8
      UniProtKB/TrEMBL
      Q7KPK2
      Conserved Domains (1) summary
      cd14500
      Location:10 → 163
      PTP-IVa; protein tyrosine phosphatase type IVA family

    3. NM_165150.2 → NP_723956.1  PRL-1 phosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61722, Q95VY8
      UniProtKB/TrEMBL
      Q7KPK2
      Related
      FBpp0080414
      Conserved Domains (1) summary
      cd14500
      Location:10 → 163
      PTP-IVa; protein tyrosine phosphatase type IVA family

    4. NM_001273558.1 → NP_001260487.1  PRL-1 phosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61722, Q95VY8
      UniProtKB/TrEMBL
      Q7KPK2
      Conserved Domains (1) summary
      cd14500
      Location:10 → 163
      PTP-IVa; protein tyrosine phosphatase type IVA family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61722.2 O61722
    Q7KPK2 Q7KPK2
    Q8SX36 Q8SX36

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