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    CG9932 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34701, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG9932provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262160
    Locus tag
    Dmel_CG9932
    See related
    AllianceGenome:FB:FBgn0262160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9932; Ef4A; elF-4A; EP2317
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval fat body; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG9932 in Genome Data Viewer
    Location:
    34A4-34A5; 2-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13021868..13060140, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13021868..13060140, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ubiquitination factor E4B Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44197 Neighboring gene long non-coding RNA:CR45447

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells. Xia B, et al. Elife, 2023 Apr 20. PMID 37078570, Free PMC Article
    2. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article
    3. How the insect immune system interacts with an obligate symbiotic bacterium. Douglas AE, et al. Proc Biol Sci, 2011 Feb 7. PMID 20719775, Free PMC Article
    4. Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila. Kang H, et al. Genes Dev, 2015 Jun 1. PMID 26063573, Free PMC Article
    5. Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster. Bogaerts-Márquez M, et al. Mol Ecol, 2021 Feb. PMID 33350518, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9932-PA
    CG9932-PC
    CG9932-PD
    CG9932-PE
    elongation factor 4a

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13021868..13060140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273500.2 → NP_001260429.1  uncharacterized protein Dmel_CG9932, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU7
      Conserved Domains (2) summary
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:812 → 832
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001259087.3 → NP_001246016.1  uncharacterized protein Dmel_CG9932, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDP0
      Conserved Domains (2) summary
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001273499.1 → NP_001260428.1  uncharacterized protein Dmel_CG9932, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBA9
      Conserved Domains (2) summary
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:812 → 832
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_135755.3 → NP_609599.1  uncharacterized protein Dmel_CG9932, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK42
      Related
      FBpp0088895
      Conserved Domains (2) summary
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDP0 M9NDP0
    M9PBA9 M9PBA9
    M9PCU7 M9PCU7
    Q8MSG6 Q8MSG6
    Q9VK42 Q9VK42

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