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    Gpdh1 Glycerol-3-phosphate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33824, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Gpdh1provided by FlyBase
    Official Full Name
    Glycerol-3-phosphate dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0001128
    Locus tag
    Dmel_CG9042
    See related
    AllianceGenome:FB:FBgn0001128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-GPD; alpha-Gpdh; alpha-GPDH; alpha-GPDH-1; alphaGpd; alphaGpdh; alphaGPDH; alphaGpdh-1; CG9042; dGpdh; Dmel\CG9042; DmG3PDH; DROGPDHA; G3pdh; G3PDH; GAPDH; Gdh; Gpd; GPD; GPDA; gpdh; Gpdh; GPDH; gpdh-1; GPDH-1; GPDH1; sn-Gpdh
    Summary
    Enables glycerol-3-phosphate dehydrogenase (NAD+) activity. Involved in several processes, including flight behavior; glycerol-3-phosphate biosynthetic process; and nicotinamide nucleotide metabolic process. Located in M band; Z disc; and cytosol. Is expressed in adult head; adult heart; and flight muscle cell. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to several human genes including GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Gpdh1 in Genome Data Viewer
    Location:
    26A3-26A3; 2-18 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5943643..5948968)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5943643..5948968)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45289 Neighboring gene Seminal fluid protein 26Ad Neighboring gene long non-coding RNA:CR44986 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetics and ontogeny of alpha-glycerophosphate dehydrogenase isozymes in Drosophila melanogaster. Wright DA, et al. Biochem Genet, 1969 Aug. PMID 5365510
    2. Structural characterization of the alpha-glycerol-3-phosphate dehydrogenase-encoding gene of Drosophila melanogaster. von Kalm L, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2500660, Free PMC Article
    3. RNA directed synthesis of catalytically active Drosophila sn-glycerol-3-phosphate dehydrogenase in Xenopus oocytes. Wright DA, et al. J Biol Chem, 1985 May 25. PMID 2581943
    4. Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster. Wilanowski TM, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618845, Free PMC Article
    5. Drosophila sn-glycerol-3-phosphate dehydrogenase isozymes are generated by alternate pathways of RNA processing resulting in different carboxyl-terminal amino acid sequences. Cook JL, et al. J Biol Chem, 1988 Aug 5. PMID 2839508

    See all (285) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila melanogaster larvae lacking both LDH and G3P dehydrogenase (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux.
      Title: Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development.
    2. Molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
      Title: The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
    3. Gene trees for the GPDH and GPO paralogs indicate that the genes expressed in the flight muscles are evolving very slowly presumably under strong purifying selection whereas the paralogs expressed in the testes are evolving more rapidly.
      Title: The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila.
    4. molecular polymorphism associated with GPDH activity could be maintained in natural populations by selection related to adaptation to alcohol
      Title: Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ethanol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerophosphate shuttle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glycerol-3-phosphate dehydrogenase 1
    Names
    5' gene
    Alpha-Glycerophosphate dehydrogenase
    CG9042-PA
    CG9042-PB
    CG9042-PC
    CG9042-PE
    CG9042-PF
    CG9042-PG
    Gpdh1-PA
    Gpdh1-PB
    Gpdh1-PC
    Gpdh1-PE
    Gpdh1-PF
    Gpdh1-PG
    alpha glycerophosphate dehydrogenase
    alpha glycerophosphate dehydrogenase 1
    alpha-glycerol phosphate dehydrogenase
    alpha-glycerol-3-phosphate dehydrogenase
    dehydrogenase
    glycerol 3 phosphate dehydrogenase
    glycerol-3-phosphate dehydrogenase
    glycerophosphate dehydrogenase
    sn-glycerol 3-phosphate dehydrogenase
    sn-glycerol-3-phosphate
    sn-glycerol-3-phosphate dehydrogenase
    NP_001260111.1
    NP_001260112.1
    NP_001260113.1
    NP_476565.1
    NP_476566.1
    NP_476567.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5943643..5948968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273184.2 → NP_001260113.1  Glycerol-3-phosphate dehydrogenase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0
      UniProtKB/TrEMBL
      M9PC43
      Conserved Domains (1) summary
      TIGR03376
      Location:6 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

    2. NM_001273183.2 → NP_001260112.1  Glycerol-3-phosphate dehydrogenase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0
      UniProtKB/TrEMBL
      B5RIM9
      Conserved Domains (1) summary
      TIGR03376
      Location:6 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

    3. NM_001273182.1 → NP_001260111.1  Glycerol-3-phosphate dehydrogenase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0
      UniProtKB/TrEMBL
      M9PET0
      Conserved Domains (3) summary
      TIGR03376
      Location:6 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:7 → 175
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:202 → 337
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    4. NM_057218.4 → NP_476566.1  Glycerol-3-phosphate dehydrogenase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0
      UniProtKB/TrEMBL
      M9PC43
      Related
      FBpp0078778
      Conserved Domains (1) summary
      TIGR03376
      Location:6 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

    5. NM_057217.4 → NP_476565.1  Glycerol-3-phosphate dehydrogenase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476565.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0
      UniProtKB/TrEMBL
      B5RIM9
      Related
      FBpp0078777
      Conserved Domains (1) summary
      TIGR03376
      Location:6 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

    6. NM_057219.4 → NP_476567.1  Glycerol-3-phosphate dehydrogenase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13706, Q27590, Q27925, Q95077, Q95TV4, Q9VML0
      UniProtKB/TrEMBL
      M9PET0
      Related
      FBpp0078779
      Conserved Domains (3) summary
      TIGR03376
      Location:6 → 343
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:7 → 175
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:202 → 337
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5RIM9 B5RIM9
    M9PC43 M9PC43
    M9PET0 M9PET0
    P13706.3 P13706

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