U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    CG17221 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33521, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG17221provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031500
    Locus tag
    Dmel_CG17221
    See related
    AllianceGenome:FB:FBgn0031500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17221; DM_7295851
    Summary
    Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in ubiquinone biosynthetic process. Predicted to be active in mitochondrial matrix. Is expressed in adult head; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG17221 in Genome Data Viewer
    Location:
    23C5-23C5; 2-8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3039976..3041890)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3039976..3041890)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Seryl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene cornichon related Neighboring gene uncharacterized protein Neighboring gene Fatty acid synthase 2 Neighboring gene small nuclear RNA Like U

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis. Park I, et al. Nat Chem Biol, 2024 Feb. PMID 37884807, Free PMC Article
    2. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article
    3. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article
    4. Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Crocker A, et al. Cell Rep, 2016 May 17. PMID 27160913, Free PMC Article
    5. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NADPH dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG17221-PA
    CG17221-PB
    CG17221-PC
    NP_001259984.1
    NP_608746.1
    NP_722873.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3039976..3041890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164523.2 → NP_722873.1  uncharacterized protein Dmel_CG17221, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZK7, Q9VQL4
      Related
      FBpp0077339
      Conserved Domains (2) summary
      cd08248
      Location:1 → 355
      RTN4I1; Human Reticulon 4 Interacting Protein 1
      COG0604
      Location:1 → 355
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    2. NM_001273055.1 → NP_001259984.1  uncharacterized protein Dmel_CG17221, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259984.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPZ3, Q8SZK7
      Conserved Domains (2) summary
      cd08248
      Location:52 → 406
      RTN4I1; Human Reticulon 4 Interacting Protein 1
      COG0604
      Location:52 → 406
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    3. NM_134902.2 → NP_608746.1  uncharacterized protein Dmel_CG17221, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPZ3, Q8SZK7
      Related
      FBpp0077340
      Conserved Domains (2) summary
      cd08248
      Location:52 → 406
      RTN4I1; Human Reticulon 4 Interacting Protein 1
      COG0604
      Location:52 → 406
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPZ3 Q8IPZ3
    Q8SZK7 Q8SZK7
    Q9VQL4 Q9VQL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools