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    pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [ Danio rerio (zebrafish) ]

    Gene ID: 394174, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pik3cdprovided by ZNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit deltaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1128
    See related
    Ensembl:ENSDARG00000003250 AllianceGenome:ZFIN:ZDB-GENE-040426-1128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63473
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within regulation of collateral sprouting in absence of injury. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; cranial ganglion; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; immunodeficiency 14; and schizophrenia. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3cd in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (29756600..29812667, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (29830059..29886126, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene calsyntenin 1 Neighboring gene catenin, beta interacting protein 1 Neighboring gene uncharacterized LOC137489135 Neighboring gene forkhead box L2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae. Elworthy S, et al. Dis Model Mech, 2023 Mar 1. PMID 36805642, Free PMC Article
    2. Selective inhibition of retinal angiogenesis by targeting PI3 kinase. Alvarez Y, et al. PLoS One, 2009 Nov 17. PMID 19924235, Free PMC Article
    3. A role for the polarity complex and PI3 kinase in branch formation within retinotectal arbors of zebrafish. Schmidt JT, et al. Dev Neurobiol, 2014 Jun. PMID 24218155
    4. Vascular toxicity of silver nanoparticles to developing zebrafish (Danio rerio). Gao J, et al. Nanotoxicology, 2016 Nov. PMID 27499207, Free PMC Article
    5. Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Bonkhofer F, et al. Nat Commun, 2019 Aug 8. PMID 31395869, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae.
      Title: Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae.
    2. PI3 kinase has a role in retinal angiogenesis
      Title: Selective inhibition of retinal angiogenesis by targeting PI3 kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63473

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Names
    phosphoinositide-3-kinase, catalytic, delta polypeptide
    NP_957493.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201199.1 → NP_957493.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

      See identical proteins and their annotated locations for NP_957493.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054896
      UniProtKB/TrEMBL
      Q7SYE7
      Related
      ENSDARP00000017757.7, ENSDART00000006120.10
      Conserved Domains (5) summary
      cd08693
      Location:315 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      cd00872
      Location:505 → 676
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05174
      Location:676 → 1038
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cl02484
      Location:188 → 280
      PI3K_rbd; PI3-kinase family, ras-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      29756600..29812667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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