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    PRNP prion protein [ Bos taurus (domestic cattle) ]

    Gene ID: 281427, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PRNPprovided by VGNC
    Official Full Name
    prion proteinprovided by VGNC
    Primary source
    VGNC:VGNC:33356
    See related
    BGD:BT10271; Ensembl:ENSBTAG00000063812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PrP; prn; AltPrP
    Orthologs
    human mouse all
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    Genomic context

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    See PRNP in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (47039937..47060168)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog C Neighboring gene small nucleolar RNA SNORD31 Neighboring gene zinc finger MYND-type containing 11 Neighboring gene prion like protein doppel Neighboring gene Ras association domain family member 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice. Espinosa JC, et al. J Virol, 2007 Jan. PMID 17079295, Free PMC Article
    2. Indels within promoter and intron 1 of bovine prion protein gene modulate the gene expression levels in the medulla oblongata of two Japanese cattle breeds. Msalya G, et al. Anim Genet, 2010 Apr. PMID 19917050
    3. Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells. Wang S, et al. Mol Biol Rep, 2010 Oct. PMID 19821149
    4. Deletion/insertion polymorphism of the prion protein gene (PRNP) in Polish red cattle, Polish White-backed cattle and European bison (Bison bonasus L., 1758). Czarnik U, et al. Genetika, 2009 Apr. PMID 19507705
    5. Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its beta isoform with high affinity. Murakami K, et al. Prion, 2008 Apr-Jun. PMID 19098441, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.
      Title: Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis.
    2. Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
      Title: Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.
    3. Deletion/insertion polymorphisms of the PRNP gene is associated with bovine spongiformencephalopathy.
      Title: Deletion/insertion polymorphisms of the prion protein gene (PRNP) in gayal (Bos frontalis).
    4. Data suggest that the E211K prion protein provides the opportunity for future analysis of physiological changes over time.
      Title: Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species.
    5. Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle
      Title: Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.
    6. the data indicate a four-rung beta-solenoid structure as a key feature for the architecture of infectious mammalian prions.
      Title: The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.
    7. Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion
      Title: Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion.
    8. Misfolded structures, with nonnative beta-strands formed in the flexible N-terminal domain of PRNP were found in acidic pH simulations.
      Title: Molecular dynamics simulations capture the misfolding of the bovine prion protein at acidic pH.
    9. This work demonstrates that this isolate is transmissible, has a BSE-H phenotype when transmitted to cattle with the K211 polymorphism, and has molecular features that distinguish it from other cases of BSE-H described in the literature.
      Title: Clinical and pathologic features of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism.
    10. Genetic characterization of PRNP promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP and bovine prion-like Shadoo (SPRN) genes, are reported.
      Title: PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140197

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major prion protein; alternative prion protein
    Names
    major scrapie-associated fibril protein 1
    prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
    prion protein PrP
    prion protein precursor PrP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271625.3 → NP_001258554.1  alternative prion protein isoform AltPrp

      See identical proteins and their annotated locations for NP_001258554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes a shorter protein from an overlapping reading frame, compared to variant 1. Alternative prion protein (AltPrp) has no similarity to the other protein encoded by this gene and localizes to the outer mitochondrial membrane.
      Source sequence(s)
      NKLS02000013
      UniProtKB/Swiss-Prot
      F7VJQ2
      UniProtKB/TrEMBL
      K0PBH2

    2. NM_001271626.3 → NP_001258555.1  major prion protein Isoform 1 precursor

      See identical proteins and their annotated locations for NP_001258555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      NKLS02000013
      UniProtKB/Swiss-Prot
      A1YVV9, P10279, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
      UniProtKB/TrEMBL
      A6YK35, D5G2D5
      Related
      ENSBTAP00000091075.1, ENSBTAT00000101610.1
      Conserved Domains (2) summary
      smart00157
      Location:25 → 251
      PRP; Major prion protein
      pfam11587
      Location:1 → 30
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    3. NM_181015.4 → NP_851358.2  major prion protein Isoform 1 precursor

      See identical proteins and their annotated locations for NP_851358.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      NKLS02000013
      UniProtKB/Swiss-Prot
      A1YVV9, P10279, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
      UniProtKB/TrEMBL
      A6YK35, D5G2D5
      Related
      ENSBTAP00000086207.1, ENSBTAT00000090572.1
      Conserved Domains (2) summary
      smart00157
      Location:25 → 251
      PRP; Major prion protein
      pfam11587
      Location:1 → 30
      Prion_bPrPp; Major prion protein bPrPp - N terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      47039937..47060168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F7VJQ2.1 GenPept UniProtKB/Swiss-Prot:F7VJQ2
    P10279.2 GenPept UniProtKB/Swiss-Prot:P10279

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