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    TLR5 toll like receptor 5 [ Bos taurus (cattle) ]

    Gene ID: 444870, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TLR5provided by VGNC
    Official Full Name
    toll like receptor 5provided by VGNC
    Primary source
    VGNC:VGNC:52835
    See related
    BGD:BT27162; Ensembl:ENSBTAG00000000477
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TLR-5
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See TLR5 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (26601164..26603747, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member B Neighboring gene dispatched RND transporter family member 1 Neighboring gene AU RNA binding protein/enoyl-CoA hydratase pseudogene Neighboring gene sushi domain containing 4 Neighboring gene coiled-coil domain containing 185

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella. Tahoun A, et al. Vet Res, 2015 Feb 19. PMID 25827709, Free PMC Article
    2. Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10. Seabury CM, et al. Genomics, 2007 Oct. PMID 17719743
    3. Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors. McGuire K, et al. Anim Genet, 2006 Feb. PMID 16441295
    4. Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination? Werling D, et al. Vet Immunol Immunopathol, 2006 Jul 15. PMID 16701904
    5. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Menzies M, et al. Vet Immunol Immunopathol, 2006 Jan 15. PMID 16095720

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040501.1 → NP_001035591.1  toll-like receptor 5 precursor

      See identical proteins and their annotated locations for NP_001035591.1

      Status: PROVISIONAL

      Source sequence(s)
      AY634631
      UniProtKB/TrEMBL
      Q2LDA0, Q6GV18
      Related
      ENSBTAP00000000604.7, ENSBTAT00000000604.7
      Conserved Domains (5) summary
      cd00116
      Location:89 → 208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:293 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693 → 825
      TIR; TIR domain
      pfam13855
      Location:313 → 372
      LRR_8; Leucine rich repeat
      cl15307
      Location:579 → 618
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26601164..26603747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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