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    MAL32 alpha-glucosidase MAL32 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852602, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MAL32
    Official Full Name
    alpha-glucosidase MAL32
    Primary source
    SGD:S000000503
    Locus tag
    YBR299W
    See related
    AllianceGenome:SGD:S000000503; FungiDB:YBR299W; VEuPathDB:YBR299W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,4-glucosidase activity and glucan 1,4-alpha-maltotriohydrolase activity. Involved in maltose catabolic process and sucrose catabolic process. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MAL32 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (805351..807105)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene maltose permease Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU24 Neighboring gene Cos2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Attachment of MAL32-encoded maltase on the outside of yeast cells improves maltotriose utilization. Dietvorst J, et al. Yeast, 2007 Jan. PMID 17192852
    2. [The decomposition of Maillard reaction products by amylolytic enzymes. 1. Reversible inhibition of alpha- and glucoamylase and alpha-glucosidase by oligosaccharide Amidori compounds]. Schumacher D, et al. Z Lebensm Unters Forsch, 1994 Oct. PMID 7839734
    3. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. Lee DS, et al. Int J Mol Med, 2007 Sep. PMID 17671744
    4. Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus. Ingavat N, et al. J Nat Prod, 2009 Nov. PMID 19824618
    5. Synthesis of hydroquinone-alpha-glucoside by alpha-glucosidase from baker's yeast. Prodanović RM, et al. Biotechnol Lett, 2005 Apr. PMID 15973488

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Only one phenolic -OH group was alpha-anomer-selectively glucosylated by alpha-glucosidase.
      Title: Synthesis of hydroquinone-alpha-glucoside by alpha-glucosidase from baker's yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maltose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maltose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maltose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sucrose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    alpha-glucosidase MAL32
    NP_009858.3
    • Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      805351..807105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178647.3 → NP_009858.3  TPA: alpha-glucosidase MAL32 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009858.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQU5, P38158
      UniProtKB/TrEMBL
      A6ZLN9, A6ZUU5, B3LML3, B5VEP2, C7GT48, F8LG06, G2WF18, N1PAX0
      Conserved Domains (2) summary
      cd11333
      Location:15 → 501
      AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
      pfam16657
      Location:511 → 583
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38158.1

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