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    mars-1 Methionine--tRNA ligase, cytoplasmic;tRNA-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178089, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mars-1
    Official Full Name
    Methionine--tRNA ligase, cytoplasmic;tRNA-binding domain-containing protein
    Primary source
    WormBase:WBGene00003415
    Locus tag
    CELE_F58B3.5
    See related
    AllianceGenome:WB:WBGene00003415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mars-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (11631941..11635487, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene LYSozyme Neighboring gene NUC153 domain-containing protein Neighboring gene ncRNA Neighboring gene Interferon-related developmental regulator N-terminal domain-containing protein Neighboring gene Splicing factor 45 Neighboring gene Transthyretin-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. let-65 is cytoplasmic methionyl tRNA synthetase in C. elegans. Alriyami MZ, et al. Meta Gene, 2014 Dec. PMID 25606464, Free PMC Article
    2. Genetic organization of the unc-22 IV gene and the adjacent region in Caenorhabditis elegans. Rogalski TM, et al. Mol Gen Genet, 1985. PMID 3866907
    3. Essential genes and deficiencies in the unc-22 IV region of Caenorhabditis elegans. Rogalski TM, et al. Genetics, 1982 Dec. PMID 7187364, Free PMC Article
    4. The unc-22(IV) region of Caenorhabditis elegans: genetic analysis of lethal mutations. Clark DV, et al. Genetics, 1988 Jun. PMID 3396868, Free PMC Article
    5. Genetic analysis and complementation by germ-line transformation of lethal mutations in the unc-22 IV region of Caenorhabditis elegans. Clark DV, et al. Mol Gen Genet, 1992 Mar. PMID 1552909

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Methionine--tRNA ligase, cytoplasmic;tRNA-binding domain-containing protein
    NP_001255570.1
    • Confirmed by transcript evidence
    NP_001255571.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11631941..11635487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268641.4 → NP_001255570.1  Methionine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20970
      Conserved Domains (4) summary
      cd07957
      Location:416 → 544
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:36 → 407
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PLN02610
      Location:21 → 898
      PLN02610; probable methionyl-tRNA synthetase
      cd02799
      Location:755 → 857
      tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

    2. NM_001268642.3 → NP_001255571.1  tRNA-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT56
      Conserved Domains (1) summary
      PLN02610
      Location:128 → 275
      PLN02610; probable methionyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20970.1

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