clpp-1 ATP-dependent Clp protease proteolytic subunit 1, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: clpp-1
Gene description: ATP-dependent Clp protease proteolytic subunit 1, mitochondrial
Locus tag: CELE_ZK970.2
See related: AllianceGenome:WB:WBGene00014172
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables serine-type endopeptidase activity. Involved in mitochondrial unfolded protein response and proteolysis. Located in mitochondrial matrix. Is expressed in intestine. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See clpp-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (10300714..10302842, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

As ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryotes utilize component(s) from the protomitochondrial symbiont to signal the UPR(mt).[clpp-1]
Title: ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK970.4 (e-PCR)
- UniSTS:320672

ZK970.3 (e-PCR)
- UniSTS:316360

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP-dependent peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein quality control for misfolded or incompletely synthesized proteins	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of endopeptidase Clp complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-dependent Clp protease proteolytic subunit 1, mitochondrial

NP_001254239.1

Confirmed by transcript evidence

NP_001254240.1

Confirmed by transcript evidence

NP_001254241.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10300714..10302842 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267311.3 → NP_001254240.1 ATP-dependent Clp protease proteolytic subunit 1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254240.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27539

Conserved Domains (1) summary

PRK00277
Location:11 → 203

clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed
NM_001267310.5 → NP_001254239.1 ATP-dependent Clp protease proteolytic subunit 1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254239.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6VQ47, H2FLG3, Q27539

Conserved Domains (1) summary

PRK00277
Location:26 → 218

clpP; ATP-dependent Clp protease proteolytic subunit; Reviewed
NM_001267312.3 → NP_001254241.1 ATP-dependent Clp protease proteolytic subunit 1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254241.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27539

Conserved Domains (1) summary

cl23717
Location:2 → 114

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...