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    HFE homeostatic iron regulator [ Pan troglodytes (chimpanzee) ]

    Gene ID: 462489, updated on 10-Oct-2024

    Summary

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    Official Symbol
    HFEprovided by VGNC
    Official Full Name
    homeostatic iron regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:2860
    Locus tag
    CK820_G0045387
    See related
    Ensembl:ENSPTRG00000017805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See HFE in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 5 NC_072403.2 (32056094..32065590)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 6 NC_072404.1 (32056022..32065598)

    Chromosome 5 - NC_072403.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134810327 Neighboring gene H2B clustered histone 3 Neighboring gene H1.2 linker histone, cluster member Neighboring gene uncharacterized LOC112209452 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H2B clustered histone 4 Neighboring gene H2A clustered histone 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence variation and haplotype structure at the human HFE locus. Toomajian C, et al. Genetics, 2002 Aug. PMID 12196404, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transferrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to iron ion starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hereditary hemochromatosis protein homolog
    Names
    hemochromatosis
    hemochromatosis protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009101.1 → NP_001009101.1  hereditary hemochromatosis protein homolog precursor

      See identical proteins and their annotated locations for NP_001009101.1

      Status: PROVISIONAL

      Source sequence(s)
      AF447807
      UniProtKB/Swiss-Prot
      P60018
      UniProtKB/TrEMBL
      A0A2I3SQG8, A0A2J8JQD9, A0A6D2VY27, K7D3A6
      Related
      ENSPTRP00000079201.1, ENSPTRT00000077752.1
      Conserved Domains (2) summary
      cd07698
      Location:206 → 298
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:27 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072403.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      32056094..32065590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016954624.4 → XP_016810113.2  hereditary hemochromatosis protein homolog isoform X1

      UniProtKB/TrEMBL
      K6Z9A0

    2. XM_016954625.3 → XP_016810114.2  hereditary hemochromatosis protein homolog isoform X2

      UniProtKB/TrEMBL
      K7AMN9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60018.1 GenPept UniProtKB/Swiss-Prot:P60018

    Gene LinkOut

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