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    GH1 growth hormone 1 [ Bos taurus (cattle) ]

    Gene ID: 280804, updated on 16-Jan-2024

    Summary

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    Gene symbol
    GH1
    Gene description
    growth hormone 1
    See related
    Ensembl:ENSBTAG00000017220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GH
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    Genomic context

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    See GH1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (48117957..48119786, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene testicular cell adhesion molecule 1 Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC132343099

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison. Lamas A, et al. Molecules, 2018 Jul 13. PMID 30011805, Free PMC Article
    2. A lncRNA promotes myoblast proliferation by up-regulating GH1. Yue Y, et al. In Vitro Cell Dev Biol Anim, 2017 Sep. PMID 28726188
    3. Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Benencia F, et al. Endocrinology, 2015 May. PMID 25521584, Free PMC Article
    4. Association between a polymorphism in intron 3 of the bovine growth hormone gene and growth traits in Holstein heifers in Antioquia. Arango J, et al. Genet Mol Res, 2014 Aug 15. PMID 25158245
    5. Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin (mTOR)C1-dependent and independent cell signaling. Sciascia Q, et al. J Dairy Sci, 2013 Apr. PMID 23462168

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of miR-93 on GH secretion in pituitary cells of Yanbian yellow cattle.
      Title: The effect of miR-93 on GH secretion in pituitary cells of Yanbian yellow cattle.
    2. Exposure to growth hormone is associated with hepatic up-regulation of cPLA2alpha and COX.
      Title: Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX.
    3. Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner.
      Title: Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner.
    4. Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells.
      Title: Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison.
    5. A microarray analysis showed that lncYYW positively regulates the expression of growth hormone 1 and its downstream genes, AKT1 and PIK3CD, in bovine myoblasts. This discovery provides a good foundation for further study of the mechanism of action of lncYYW during bovine myoblast development
      Title: A lncRNA promotes myoblast proliferation by up-regulating GH1.
    6. bGH mice had increased body weight and decreased percent fat mass. Serum FGF21 levels were significantly elevated in bGH mice. Expression of Fgf21, Fgfr1, and Klb mRNA in white AT and liver were downregulated or unchanged in bGH mice.
      Title: Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice.
    7. GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN/DraI.
      Title: Effect of Genetic Polymorphisms in GH/Hpa II and MSTN / Dra I Loci on Body Weight in Friesian Bull Calves.
    8. An SNP GH4.1 in a growth hormone gene was significantly related to a weaning weight.
      Title: Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle.
    9. The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.
      Title: Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle.
    10. Male bovine GH transgenic mice have decreased adiposity, and have increased regulatory T cells and macrophages in mesenteric and subcutaneous white adipose tissue.
      Title: Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    somatotropin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180996.1 → NP_851339.1  somatotropin precursor

      See identical proteins and their annotated locations for NP_851339.1

      Status: PROVISIONAL

      Source sequence(s)
      M57764
      UniProtKB/Swiss-Prot
      A4GX96, P01246, Q28117, Q3LS73
      UniProtKB/TrEMBL
      B0FPG4, B0FPG6, I6WN98
      Related
      ENSBTAP00000022885.7, ENSBTAT00000022885.7
      Conserved Domains (1) summary
      cd10285
      Location:36 → 215
      somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48117957..48119786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005220810.4 → XP_005220867.2  somatotropin isoform X1

      UniProtKB/TrEMBL
      B0FPG4
      Conserved Domains (1) summary
      cd10285
      Location:63 → 243
      somatotropin_like; Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01246.1 GenPept UniProtKB/Swiss-Prot:P01246

    Gene LinkOut

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