USP37 ubiquitin specific peptidase 37 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: USP37provided by VGNC
Official Full Name: ubiquitin specific peptidase 37provided by VGNC
Primary source: VGNC:VGNC:98404
See related: Ensembl:ENSSSCG00000016194
Gene type: protein coding
RefSeq status: MODEL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in ovary (RPKM 5.1), spleen (RPKM 3.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	15	NC_010457.5 (120492552..120590230, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	15	NC_010457.4 (133508194..133605015, complement)

Chromosome 15 - NC_010457.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

236B15' (e-PCR)
- UniSTS:186581

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 37

Names: Deubiquitinating enzyme 37; Ubiquitin carboxyl-terminal hydrolase 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010457.5 Reference Sscrofa11.1 Primary Assembly

Range

120492552..120590230 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003133658.6 → XP_003133706.4 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

UniProtKB/TrEMBL

A0A480S3Z7, A0A480TJS3, A0A8D0JRC0

Conserved Domains (3) summary

cd02257
Location:863 → 950

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:343 → 607

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_005672197.3 → XP_005672254.2 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

UniProtKB/TrEMBL

A0A480S3Z7, A0A480TJS3, A0A8D0JRC0

Conserved Domains (3) summary

cd02257
Location:863 → 950

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:343 → 607

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_021076476.1 → XP_020932135.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X4

UniProtKB/TrEMBL

A0A4X1UKV0

Conserved Domains (2) summary

cd02257
Location:753 → 840

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:233 → 497

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_021076475.1 → XP_020932134.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X2

UniProtKB/TrEMBL

A0A2C9F3C4, A0A8D0JIU5

Conserved Domains (3) summary

cd02257
Location:841 → 928

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:343 → 607

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_013984488.2 → XP_013839942.2 ubiquitin carboxyl-terminal hydrolase 37 isoform X3

UniProtKB/TrEMBL

A0A8D0WHR0

Conserved Domains (3) summary

cd02257
Location:808 → 895

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:343 → 558

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_005672200.3 → XP_005672257.2 ubiquitin carboxyl-terminal hydrolase 37 isoform X2

UniProtKB/TrEMBL

A0A2C9F3C4, A0A8D0JIU5

Related

ENSSSCP00000017157.5, ENSSSCT00000017635.5

Conserved Domains (3) summary

cd02257
Location:841 → 928

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:343 → 607

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37