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    Kansl1l KAT8 regulatory NSL complex subunit 1-like [ Mus musculus (house mouse) ]

    Gene ID: 68691, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kansl1lprovided by MGI
    Official Full Name
    KAT8 regulatory NSL complex subunit 1-likeprovided by MGI
    Primary source
    MGI:MGI:1915941
    See related
    Ensembl:ENSMUSG00000026004 AllianceGenome:MGI:1915941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4189; 1190030G24; 1110028C15Rik; C430010P07Rik
    Summary
    Predicted to enable histone acetyltransferase binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of NSL complex. Orthologous to human KANSL1L (KAT8 regulatory NSL complex subunit 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 1.9), bladder adult (RPKM 1.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kansl1l in Genome Data Viewer
    Location:
    1 C3; 1 33.61 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66758402..66856754, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66719243..66817596, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene predicted gene, 25411 Neighboring gene STARR-seq mESC enhancer starr_01189 Neighboring gene unc-80, NALCN activator Neighboring gene predicted gene, 39655 Neighboring gene STARR-seq mESC enhancer starr_01190 Neighboring gene STARR-seq mESC enhancer starr_01191 Neighboring gene STARR-positive B cell enhancer ABC_E5767 Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene STARR-positive B cell enhancer ABC_E11073 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:66862655-66862957 Neighboring gene STARR-positive B cell enhancer ABC_E4319 Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5768 Neighboring gene predicted gene 15793 Neighboring gene predicted gene, 27934 Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Cesari E, et al. Nucleic Acids Res, 2024 May 8. PMID 38324473, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4189, MGC175997, AC118589.2

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone acetyltransferase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of H4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    KAT8 regulatory NSL complex subunit 1-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122738.2 → NP_001116210.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118589, AC124389
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:764 → 884
      PEHE; PEHE domain

    2. NM_001357156.2 → NP_001344085.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118589, AC124389
      Consensus CDS
      CCDS35603.1
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:755 → 875
      PEHE; PEHE domain

    3. NM_001357157.2 → NP_001344086.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC118589, AC124389
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:754 → 845
      PEHE; PEHE domain

    4. NM_001368830.2 → NP_001355759.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC118589, AC124389
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:720 → 811
      PEHE; PEHE domain

    5. NM_001431335.1 → NP_001418264.1  KAT8 regulatory NSL complex subunit 1-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC118589, AC124389
      UniProtKB/Swiss-Prot
      B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5

    6. NM_177645.5 → NP_808313.3  KAT8 regulatory NSL complex subunit 1-like protein isoform 2

      See identical proteins and their annotated locations for NP_808313.3

      Status: VALIDATED

      Source sequence(s)
      AC118589, AC124389
      Consensus CDS
      CCDS35603.1
      UniProtKB/TrEMBL
      B2RUA4
      Related
      ENSMUSP00000063843.4, ENSMUST00000068168.10
      Conserved Domains (1) summary
      pfam15275
      Location:755 → 875
      PEHE; PEHE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      66758402..66856754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322317.2 → XP_017177806.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X12

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:754 → 845
      PEHE; PEHE domain

    2. XM_017322311.2 → XP_017177800.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X5

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:798 → 889
      PEHE; PEHE domain

    3. XM_006496241.3 → XP_006496304.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

      Conserved Domains (1) summary
      pfam15275
      Location:799 → 919
      PEHE; PEHE domain

    4. XM_030242671.2 → XP_030098531.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X13

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:720 → 811
      PEHE; PEHE domain

    5. XM_030242649.2 → XP_030098509.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

      UniProtKB/Swiss-Prot
      B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:799 → 919
      PEHE; PEHE domain

    6. XM_030242665.2 → XP_030098525.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X9

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:763 → 883
      PEHE; PEHE domain

    7. XM_036153352.1 → XP_036009245.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X8

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:764 → 884
      PEHE; PEHE domain

    8. XM_011238574.3 → XP_011236876.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011236876.1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    9. XM_036153358.1 → XP_036009251.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X10

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:755 → 875
      PEHE; PEHE domain

    10. XM_036153341.1 → XP_036009234.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

      UniProtKB/Swiss-Prot
      B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:799 → 919
      PEHE; PEHE domain

    11. XM_011238571.3 → XP_011236873.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011236873.1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    12. XM_017322316.2 → XP_017177805.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X11

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:755 → 846
      PEHE; PEHE domain

    13. XM_011238578.2 → XP_011236880.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X4

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:799 → 890
      PEHE; PEHE domain

    14. XM_011238580.2 → XP_011236882.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X7

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:789 → 880
      PEHE; PEHE domain

    15. XM_011238579.2 → XP_011236881.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X6

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:790 → 881
      PEHE; PEHE domain

    16. XM_011238576.2 → XP_011236878.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X2

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:833 → 924
      PEHE; PEHE domain

    17. XM_011238570.2 → XP_011236872.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011236872.1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    18. XM_036153357.1 → XP_036009250.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X9

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:763 → 883
      PEHE; PEHE domain

    19. XM_036153363.1 → XP_036009256.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X18

      UniProtKB/TrEMBL
      F6ULJ7
      Related
      ENSMUSP00000118603.2, ENSMUST00000129190.8
      Conserved Domains (1) summary
      pfam15275
      Location:338 → 458
      PEHE; PEHE domain

    20. XM_036153332.1 → XP_036009225.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    21. XM_036153365.1 → XP_036009258.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X19

      Conserved Domains (1) summary
      pfam15275
      Location:294 → 414
      PEHE; PEHE domain

    22. XM_006496249.3 → XP_006496312.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X15

      See identical proteins and their annotated locations for XP_006496312.1

      UniProtKB/TrEMBL
      F6ULJ7
      Conserved Domains (1) summary
      pfam15275
      Location:467 → 558
      PEHE; PEHE domain

    23. XM_030242669.2 → XP_030098529.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X13

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:720 → 811
      PEHE; PEHE domain

    24. XM_036153359.1 → XP_036009252.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X10

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:755 → 875
      PEHE; PEHE domain

    25. XM_011238575.3 → XP_011236877.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011236877.1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    26. XM_011238583.3 → XP_011236885.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X15

      See identical proteins and their annotated locations for XP_011236885.1

      UniProtKB/TrEMBL
      F6ULJ7
      Conserved Domains (1) summary
      pfam15275
      Location:467 → 558
      PEHE; PEHE domain

    27. XM_011238573.3 → XP_011236875.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011236875.1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    28. XM_011238582.4 → XP_011236884.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X15

      See identical proteins and their annotated locations for XP_011236884.1

      UniProtKB/TrEMBL
      F6ULJ7
      Conserved Domains (1) summary
      pfam15275
      Location:467 → 558
      PEHE; PEHE domain

    29. XM_011238577.4 → XP_011236879.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X3

      See identical proteins and their annotated locations for XP_011236879.1

      UniProtKB/Swiss-Prot
      B2KGC3, E9QLD1, Q3TC00, Q5DTI6, Q8BNM1, Q8C4R5
      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:799 → 919
      PEHE; PEHE domain

    30. XM_011238572.4 → XP_011236874.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X1

      See identical proteins and their annotated locations for XP_011236874.1

      UniProtKB/TrEMBL
      B2RUA4
      Conserved Domains (1) summary
      pfam15275
      Location:834 → 954
      PEHE; PEHE domain

    31. XM_011238581.4 → XP_011236883.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X14

      UniProtKB/TrEMBL
      E9QLE2
      Related
      ENSMUSP00000109620.2, ENSMUST00000113987.2

    32. XM_011238584.4 → XP_011236886.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X16

    33. XM_036153362.1 → XP_036009255.1  KAT8 regulatory NSL complex subunit 1-like protein isoform X17

    RNA

    1. XR_001785576.2 RNA Sequence

    2. XR_003946490.2 RNA Sequence

    3. XR_004934169.1 RNA Sequence

    4. XR_004934170.1 RNA Sequence

    5. XR_003946488.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033526.1: Suppressed sequence

      Description
      NM_001033526.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTI6.3 GenPept UniProtKB/Swiss-Prot:Q5DTI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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