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    POLR3F RNA polymerase III subunit F [ Homo sapiens (human) ]

    Gene ID: 10621, updated on 3-Nov-2024

    Summary

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    Official Symbol
    POLR3Fprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Fprovided by HGNC
    Primary source
    HGNC:HGNC:15763
    See related
    Ensembl:ENSG00000132664 MIM:617455; AllianceGenome:HGNC:15763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C34; RPC6; RPC39; IMD101
    Summary
    The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See POLR3F in Genome Data Viewer
    Location:
    20p11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18467390..18484646)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18518490..18535746)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18448034..18465290)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:18447554-18448172 Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18477654-18478218 Neighboring gene RB binding protein 9, serine hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence. Wang Y, et al. Biochim Biophys Acta, 2011 Jan. PMID 20888865, Free PMC Article
    2. Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters. Paulsen T, et al. Nucleic Acids Res, 2019 May 21. PMID 30828735, Free PMC Article
    3. PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription. Zhou D, et al. J Mol Signal, 2007 Jul 5. PMID 17612402, Free PMC Article
    4. Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III. Jones E, et al. Exp Cell Res, 2000 Jan 10. PMID 10623476
    5. Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2. Mertens C, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11416169, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Immunodeficiency 101 (varicella zoster virus-specific)
    MedGen: C5676983 OMIM: 619872 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of polymerase (RNA) III (DNA directed) polypeptide F (POLR3F) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC13517

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed 5'-3' RNA polymerase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase III NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC6
    Names
    RNA polymerase III C39 subunit
    RNA polymerase III subunit C6
    polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
    polymerase (RNA) III subunit F
    NP_001269455.1
    NP_001397750.1
    NP_006457.2
    XP_047295792.1
    XP_047295793.1
    XP_054178826.1
    XP_054178827.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282526.2 → NP_001269455.1  DNA-directed RNA polymerase III subunit RPC6 isoform 2

      See identical proteins and their annotated locations for NP_001269455.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL121893
      Consensus CDS
      CCDS93016.1
      UniProtKB/TrEMBL
      Q05DB8, Q53FI8
      Related
      ENSP00000513375.1, ENST00000462997.6
      Conserved Domains (1) summary
      pfam05158
      Location:1 → 274
      RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

    2. NM_001410821.1 → NP_001397750.1  DNA-directed RNA polymerase III subunit RPC6 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL121893
      Consensus CDS
      CCDS93015.1
      UniProtKB/TrEMBL
      A0A8V8TMS0
      Related
      ENSP00000513372.1, ENST00000697649.1

    3. NM_006466.4 → NP_006457.2  DNA-directed RNA polymerase III subunit RPC6 isoform 1

      See identical proteins and their annotated locations for NP_006457.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL121893
      Consensus CDS
      CCDS13135.1
      UniProtKB/Swiss-Prot
      A8K4C7, O15319, Q9H1D9
      UniProtKB/TrEMBL
      Q53FI8
      Related
      ENSP00000366828.4, ENST00000377603.5
      Conserved Domains (1) summary
      pfam05158
      Location:12 → 315
      RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

    RNA

    1. NR_104209.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL121893
      Related
      ENST00000697656.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      18467390..18484646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439836.1 → XP_047295792.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

      Related
      ENSP00000513382.1, ENST00000697657.1

    2. XM_047439837.1 → XP_047295793.1  DNA-directed RNA polymerase III subunit RPC6 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TL53
      Related
      ENSP00000513376.1, ENST00000697652.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      18518490..18535746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322851.1 → XP_054178826.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

    2. XM_054322852.1 → XP_054178827.1  DNA-directed RNA polymerase III subunit RPC6 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TL53
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H1D9.1 GenPept UniProtKB/Swiss-Prot:Q9H1D9

    Gene LinkOut

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