apol1 apolipoprotein L, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: apol1provided by ZNC
Official Full Name: apolipoprotein L, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3217
See related: Ensembl:ENSDARG00000007425 AllianceGenome:ZFIN:ZDB-GENE-030131-3217
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fa95b12; wu:fc30h04; si:rp71-1g18.12
Summary: Predicted to enable lipid binding activity. Acts upstream of or within glomerular filtration; podocyte development; and pronephric glomerulus morphogenesis. Predicted to be located in extracellular region and membrane. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; integument; liver; and pleuroperitoneal region. Used to study kidney disease. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including APOL1 (apolipoprotein L1) and APOL4 (apolipoprotein L4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (37967875..37974727)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (37985522..37992399)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin
Title: Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin.

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General gene information

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Markers

AI722732 (e-PCR)
- UniSTS:205986

fc30h04.x1 (e-PCR)
- UniSTS:193499

fa95b12 (e-PCR)
- UniSTS:188892

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glomerular filtration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric glomerulus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apolipoprotein L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030138.1 → NP_001025309.1 apolipoprotein L1

See identical proteins and their annotated locations for NP_001025309.1

Status: PROVISIONAL

Source sequence(s)

AL627248

UniProtKB/TrEMBL

Q7T131

Related

ENSDARP00000134943.1, ENSDART00000165085.2

Conserved Domains (1) summary

pfam05461
Location:14 → 310

ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

37967875..37974727

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171301.4 → XP_005171358.1 apolipoprotein L1 isoform X1

UniProtKB/TrEMBL

A0A8M2BJ26

Conserved Domains (1) summary

pfam05461
Location:153 → 449

ApoL; Apolipoprotein L
XM_005171302.4 → XP_005171359.1 apolipoprotein L1 isoform X2

UniProtKB/TrEMBL

A0A8M2BIK2

Conserved Domains (1) summary

pfam05461
Location:152 → 448

ApoL; Apolipoprotein L
XM_005171303.4 → XP_005171360.1 apolipoprotein L1 isoform X3

UniProtKB/TrEMBL

A0A8M2BIK6

Conserved Domains (1) summary

pfam05461
Location:128 → 424

ApoL; Apolipoprotein L