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    zgc:173742 zgc:173742 [ Danio rerio (zebrafish) ]

    Gene ID: 334557, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zgc:173742provided by ZNC
    Official Full Name
    zgc:173742provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6489
    See related
    Ensembl:ENSDARG00000004529 AllianceGenome:ZFIN:ZDB-GENE-030131-6489
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fl27b11; wu:fl27b11; si:dkey-204j6.1
    Summary
    Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See zgc:173742 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (14276613..14332060)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (14308046..14363548)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene cadherin 13, H-cadherin (heart) Neighboring gene si:dkey-246g23.2 Neighboring gene malonyl-CoA decarboxylase Neighboring gene heat shock factor binding protein 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA topoisomerase I, mitochondrial; zgc:173742
    XP_002665372.2
    XP_005170014.1
    XP_021328923.1
    XP_021328924.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      14276613..14332060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002665326.7 → XP_002665372.2  DNA topoisomerase I, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_002665372.2

      UniProtKB/TrEMBL
      A0A8M2BH93
      Conserved Domains (4) summary
      smart00435
      Location:330 → 704
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:402 → 605
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:185 → 399
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:665 → 733
      Topo_C_assoc; C-terminal topoisomerase domain

    2. XM_005169957.5 → XP_005170014.1  DNA topoisomerase I, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005170014.1

      UniProtKB/TrEMBL
      A0A8M2BH93
      Related
      ENSDARP00000009334.9, ENSDART00000006628.10
      Conserved Domains (4) summary
      smart00435
      Location:330 → 704
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:402 → 605
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:185 → 399
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:665 → 733
      Topo_C_assoc; C-terminal topoisomerase domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395014.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      494258..541138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473248.2 → XP_021328923.1  DNA topoisomerase I, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M9PVS7
      Conserved Domains (2) summary
      smart00435
      Location:330 → 707
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam02919
      Location:185 → 399
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment

    2. XM_021473249.2 → XP_021328924.1  DNA topoisomerase I, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M9PVS7
      Conserved Domains (2) summary
      smart00435
      Location:330 → 707
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam02919
      Location:185 → 399
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    Nucleotide Protein Strain
    Heading Accession and Version

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