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    Zic2 Zic family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361096, updated on 2-Nov-2024

    Summary

    Official Symbol
    Zic2provided by RGD
    Official Full Name
    Zic family member 2provided by RGD
    Primary source
    RGD:1311174
    See related
    EnsemblRapid:ENSRNOG00000054879 AllianceGenome:RGD:1311174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Predicted to be involved in several processes, including nervous system development; regulation of DNA-templated transcription; and visual perception. Predicted to act upstream of or within several processes, including neural crest cell differentiation; neural tube closure; and nodal signaling pathway. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 79.3) See more
    Orthologs
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    Genomic context

    See Zic2 in Genome Data Viewer
    Location:
    15q25
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (105982711..105988167)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (99576697..99581522)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (108908366..108913812)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Zic family member 5 Neighboring gene uncharacterized LOC120093115 Neighboring gene similar to Preli Neighboring gene ribosomal protein L24, pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system segmentation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural crest cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural plate development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in paraxial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinal ganglion cell axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein ZIC 2
    Names
    Zic family member 2 (odd-paired homolog, Drosophila)
    zinc finger protein of the cerebellum 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108392.2NP_001101862.2  zinc finger protein ZIC 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JWR6, A6HUM0
      Related
      ENSRNOP00000069986.2, ENSRNOT00000089455.3
      Conserved Domains (3) summary
      COG5189
      Location:328412
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:306326
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam18366
      Location:249294
      zf_ZIC; Zic proteins zinc finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      105982711..105988167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093543.2XP_038949471.1  zinc finger protein ZIC 2 isoform X1