Arnt2 aryl hydrocarbon receptor nuclear translocator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arnt2provided by MGI
Official Full Name: aryl hydrocarbon receptor nuclear translocator 2provided by MGI
Primary source: MGI:MGI:107188
See related: Ensembl:ENSMUSG00000015709 AllianceGenome:MGI:107188
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hif-2b; bHLHe1; mKIAA0307
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; aryl hydrocarbon receptor binding activity; and protein heterodimerization activity. Involved in central nervous system development; in utero embryonic development; and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 45.1), CNS E18 (RPKM 38.6) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 48.35 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (83895486..84059201, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (84246274..84411741, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy.
Title: ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy.
In the absence of synaptic excitation, ARNT2 recruits the NCoR2 co-repressor complex to suppress neuronal activity-dependent regulatory elements and maintain low basal levels of inducible genes. in response to heightened neuronal activity, ARNT2 recruits NPAS4 to activity-dependent regulatory elements to induce transcription and thereby increase somatic inhibitory input.
Title: ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation.
These findings establish a requirement for ARNT2-dependent genes in the maintenance of the homeostatic feeding response, necessary for prevention of obesity and obesity-related diseases.
Title: A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis.
The data of this study support ARNT2 as a neuronal transcription factor whose sustained expression is linked to neuronal and axonal health, protection that may primarily be driven through its partnering with Npas4 to influence BDNF expression.
Title: Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis.
Cap-analysis of gene expression (CAGE) data points to Arnt2 as a key regulator in hippocampus.
Title: Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE.
The differential binding of AhR by Arnt and Arnt2 can be ascribed to a single His/Pro amino acid difference in the PASB region of Arnt and Arnt2.
Title: Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.
data suggest that ARNT2/HIF-2beta is required at high levels during nephrogenesis in distal tubules and later exclusively in thick ascending limb
Title: Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D63644 (e-PCR)
- UniSTS:124843

Arnt2 (e-PCR), detects polymorphism
- UniSTS:528854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables aryl hydrocarbon receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	TAS Traceable Author Statement more info	PubMed
involved_in response to toxic substance	TAS Traceable Author Statement more info	PubMed
involved_in response to xenobiotic stimulus	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aryl hydrocarbon receptor nuclear translocator 2

Names: ARNT protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411920.1 → NP_001398849.1 aryl hydrocarbon receptor nuclear translocator 2 isoform b

Status: VALIDATED

Source sequence(s)

AC101659, AC101776
NM_001411921.1 → NP_001398850.1 aryl hydrocarbon receptor nuclear translocator 2 isoform c

Status: VALIDATED

Source sequence(s)

AC101659, AC101776
NM_001411922.1 → NP_001398851.1 aryl hydrocarbon receptor nuclear translocator 2 isoform c

Status: VALIDATED

Source sequence(s)

AC101659, AC101776
NM_001411923.1 → NP_001398852.1 aryl hydrocarbon receptor nuclear translocator 2 isoform c

Status: VALIDATED

Source sequence(s)

AC101659, AC101776

Related

ENSMUSP00000146413.2, ENSMUST00000208232.2
NM_001411924.1 → NP_001398853.1 aryl hydrocarbon receptor nuclear translocator 2 isoform d

Status: VALIDATED

Source sequence(s)

AC101659, AC101776
NM_001411925.1 → NP_001398854.1 aryl hydrocarbon receptor nuclear translocator 2 isoform e

Status: VALIDATED

Source sequence(s)

AC101659, AC101776
NM_007488.4 → NP_031514.3 aryl hydrocarbon receptor nuclear translocator 2 isoform a

See identical proteins and their annotated locations for NP_031514.3

Status: VALIDATED

Source sequence(s)

AC101659, AC101776

Consensus CDS

CCDS59733.1

UniProtKB/Swiss-Prot

Q61324, Q7TQG2, Q8CHG9

Related

ENSMUSP00000082154.4, ENSMUST00000085077.5

Conserved Domains (3) summary

pfam00989
Location:137 → 243

PAS; PAS fold

pfam14598
Location:336 → 436

PAS_11; PAS domain

cd18947
Location:62 → 124

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

83895486..84059201 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152603.1 → XP_036008496.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X3

Conserved Domains (3) summary

cd18947
Location:51 → 113

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

pfam00989
Location:126 → 232

PAS; PAS fold

pfam14598
Location:325 → 425

PAS_11; PAS domain
XM_036152601.1 → XP_036008494.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X3

Conserved Domains (3) summary

cd18947
Location:51 → 113

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

pfam00989
Location:126 → 232

PAS; PAS fold

pfam14598
Location:325 → 425

PAS_11; PAS domain
XM_036152600.1 → XP_036008493.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X3

Conserved Domains (3) summary

cd18947
Location:51 → 113

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

pfam00989
Location:126 → 232

PAS; PAS fold

pfam14598
Location:325 → 425

PAS_11; PAS domain
XM_006507238.4 → XP_006507301.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X1

Conserved Domains (3) summary

pfam00989
Location:137 → 243

PAS; PAS fold

pfam14598
Location:336 → 436

PAS_11; PAS domain

cd18947
Location:62 → 124

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
XM_030242017.2 → XP_030097877.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X3

Related

ENSMUSP00000147129.2, ENSMUST00000209133.2

Conserved Domains (3) summary

cd18947
Location:51 → 113

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

pfam00989
Location:126 → 232

PAS; PAS fold

pfam14598
Location:325 → 425

PAS_11; PAS domain
XM_036152602.1 → XP_036008495.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X3

Conserved Domains (3) summary

cd18947
Location:51 → 113

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

pfam00989
Location:126 → 232

PAS; PAS fold

pfam14598
Location:325 → 425

PAS_11; PAS domain
XM_006507243.2 → XP_006507306.1 aryl hydrocarbon receptor nuclear translocator 2 isoform X4

Conserved Domains (3) summary

pfam00989
Location:122 → 228

PAS; PAS fold

pfam14598
Location:321 → 421

PAS_11; PAS domain

cl00081
Location:54 → 109

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily