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    Osbpl9 oxysterol binding protein-like 9 [ Mus musculus (house mouse) ]

    Gene ID: 100273, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Osbpl9provided by MGI
    Official Full Name
    oxysterol binding protein-like 9provided by MGI
    Primary source
    MGI:MGI:1923784
    See related
    Ensembl:ENSMUSG00000028559 AllianceGenome:MGI:1923784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orp-9; 2600011I06Rik
    Summary
    Predicted to enable sterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus; cytosol; and membrane. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; immune system; and liver. Orthologous to human OSBPL9 (oxysterol binding protein like 9). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.6), kidney adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl9 in Genome Data Viewer
    Location:
    4 C7; 4 50.77 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108918342..109059469, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109061145..109202272, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RAB3B, member RAS oncogene family Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene nardilysin convertase Neighboring gene microRNA 761 Neighboring gene STARR-seq mESC enhancer starr_11061 Neighboring gene STARR-seq mESC enhancer starr_11062 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108777798-108778099 Neighboring gene predicted gene, 32581 Neighboring gene STARR-positive B cell enhancer ABC_E521 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703 Neighboring gene STARR-positive B cell enhancer ABC_E11807 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene calreticulin 4 Neighboring gene STARR-positive B cell enhancer ABC_E2703 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene predicted gene, 52753

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
    2. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Gauci S, et al. Anal Chem, 2009 Jun 1. PMID 19413330
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30367, MGC38458

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 9
    Names
    OSBP-related protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134791.2 → NP_001128263.1  oxysterol-binding protein-related protein 9 isoform c

      See identical proteins and their annotated locations for NP_001128263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) has multiple differences in the 5' UTR and 5' coding region, compared to variant a, resulting in a protein (isoform c) with a shorter and distinct N-terminus when compared to isoform a.
      Source sequence(s)
      AK035658, AL627406, BC089163, CJ088630
      Consensus CDS
      CCDS51257.1
      UniProtKB/TrEMBL
      F6UHR6, Q5FWX7
      Related
      ENSMUSP00000124112.2, ENSMUST00000160271.8
      Conserved Domains (1) summary
      pfam01237
      Location:267 → 613
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001346502.2 → NP_001333431.1  oxysterol-binding protein-related protein 9 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) contains an alternate, internal exon compared to variant a. It encodes isoform d, which is longer than isoform a.
      Source sequence(s)
      AK035658, AL627103, BE861957, CA318269, CK621564, CN692679, CO043799, DV651580
      Consensus CDS
      CCDS84775.1
      UniProtKB/TrEMBL
      A0A0A6YXH3, F6UHR6
      Related
      ENSMUSP00000141991.2, ENSMUST00000194478.6
      Conserved Domains (2) summary
      cd13290
      Location:5 → 106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:387 → 733
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001355190.1 → NP_001342119.1  oxysterol-binding protein-related protein 9 isoform e

      Status: VALIDATED

      Source sequence(s)
      AK035658, AL627406, BQ176735, BQ745311, BU706118, CD353630, CX563312, DV651580, DV657501
      Conserved Domains (1) summary
      pfam01237
      Location:199 → 545
      Oxysterol_BP; Oxysterol-binding protein

    4. NM_001355191.1 → NP_001342120.1  oxysterol-binding protein-related protein 9 isoform e

      Status: VALIDATED

      Source sequence(s)
      AK035658, AL627406, BQ176735, BQ745311, BU706118, CX563312, DV651580, DV657501
      Conserved Domains (1) summary
      pfam01237
      Location:199 → 545
      Oxysterol_BP; Oxysterol-binding protein

    5. NM_001368727.1 → NP_001355656.1  oxysterol-binding protein-related protein 9 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL627103, AL627406
      Consensus CDS
      CCDS89802.1
      UniProtKB/Swiss-Prot
      A2A8Z1, A2A9Q8
      UniProtKB/TrEMBL
      F6UHR6
      Related
      ENSMUSP00000030288.8, ENSMUST00000030288.14
      Conserved Domains (2) summary
      cd13290
      Location:5 → 106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:377 → 723
      Oxysterol_BP; Oxysterol-binding protein

    6. NM_133885.4 → NP_598646.4  oxysterol-binding protein-related protein 9 isoform a

      See identical proteins and their annotated locations for NP_598646.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK075981, AK131984, AL627103, AL627406
      Consensus CDS
      CCDS38835.2
      UniProtKB/TrEMBL
      E9PXZ2, F6UHR6
      Related
      ENSMUSP00000124370.3, ENSMUST00000162787.9
      Conserved Domains (2) summary
      cd13290
      Location:5 → 106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:364 → 710
      Oxysterol_BP; Oxysterol-binding protein

    7. NM_173350.3 → NP_775485.2  oxysterol-binding protein-related protein 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) has multiple differences in the 5' UTR and 5' coding region, compared to variant a, resulting in a protein (isoform b) with a shorter and distinct N-terminus when compared to isoform a.
      Source sequence(s)
      AK035658, AL627406, CJ088630
      Consensus CDS
      CCDS51258.1
      UniProtKB/TrEMBL
      F6UHR6
      Related
      ENSMUSP00000081396.7, ENSMUST00000084366.13
      Conserved Domains (1) summary
      pfam01237
      Location:280 → 626
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108918342..109059469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502617.4 → XP_006502680.2  oxysterol-binding protein-related protein 9 isoform X1

      UniProtKB/TrEMBL
      F6UHR6
      Related
      ENSMUSP00000124742.2, ENSMUST00000160774.8
      Conserved Domains (2) summary
      cd13290
      Location:5 → 106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:400 → 746
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_036163549.1 → XP_036019442.1  oxysterol-binding protein-related protein 9 isoform X7

      UniProtKB/TrEMBL
      Q8R0G3
      Conserved Domains (1) summary
      pfam01237
      Location:212 → 558
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_030253060.2 → XP_030108920.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199 → 545
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_036163548.1 → XP_036019441.1  oxysterol-binding protein-related protein 9 isoform X7

      UniProtKB/TrEMBL
      Q8R0G3
      Conserved Domains (1) summary
      pfam01237
      Location:212 → 558
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_030253064.2 → XP_030108924.1  oxysterol-binding protein-related protein 9 isoform X9

      Conserved Domains (1) summary
      pfam01237
      Location:35 → 381
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_030253061.2 → XP_030108921.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199 → 545
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_030253057.1 → XP_030108917.1  oxysterol-binding protein-related protein 9 isoform X2

      UniProtKB/TrEMBL
      F6UHR6
      Conserved Domains (2) summary
      pfam01237
      Location:359 → 705
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1 → 65
      PH-like; Pleckstrin homology-like domain

    8. XM_036163550.1 → XP_036019443.1  oxysterol-binding protein-related protein 9 isoform X9

      Conserved Domains (1) summary
      pfam01237
      Location:35 → 381
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_030253062.1 → XP_030108922.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199 → 545
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_036163547.1 → XP_036019440.1  oxysterol-binding protein-related protein 9 isoform X5

      UniProtKB/TrEMBL
      F6UHR6
      Conserved Domains (2) summary
      pfam01237
      Location:310 → 656
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:13 → 39
      PH-like; Pleckstrin homology-like domain

    11. XM_036163546.1 → XP_036019439.1  oxysterol-binding protein-related protein 9 isoform X3

      UniProtKB/TrEMBL
      F6UHR6
      Conserved Domains (2) summary
      pfam01237
      Location:333 → 679
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:13 → 39
      PH-like; Pleckstrin homology-like domain

    12. XM_030253059.2 → XP_030108919.1  oxysterol-binding protein-related protein 9 isoform X6

      UniProtKB/TrEMBL
      E9Q6C1, F6UHR6
      Related
      ENSMUSP00000125714.2, ENSMUST00000161363.2
      Conserved Domains (2) summary
      pfam01237
      Location:297 → 643
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:13 → 39
      PH-like; Pleckstrin homology-like domain

    13. XM_030253063.1 → XP_030108923.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199 → 545
      Oxysterol_BP; Oxysterol-binding protein

    14. XM_011240378.1 → XP_011238680.1  oxysterol-binding protein-related protein 9 isoform X7

      See identical proteins and their annotated locations for XP_011238680.1

      UniProtKB/TrEMBL
      Q8R0G3
      Conserved Domains (1) summary
      pfam01237
      Location:212 → 558
      Oxysterol_BP; Oxysterol-binding protein

    15. XM_030253058.2 → XP_030108918.1  oxysterol-binding protein-related protein 9 isoform X4

      UniProtKB/TrEMBL
      F6UHR6
      Conserved Domains (2) summary
      pfam01237
      Location:320 → 666
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:13 → 39
      PH-like; Pleckstrin homology-like domain

    16. XM_030253065.1 → XP_030108925.1  oxysterol-binding protein-related protein 9 isoform X9

      Conserved Domains (1) summary
      pfam01237
      Location:35 → 381
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A8Z1.1 GenPept UniProtKB/Swiss-Prot:A2A8Z1

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