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    CAPN2 calpain 2 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009092, updated on 8-Mar-2024

    Summary

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    Gene symbol
    CAPN2
    Gene description
    calpain 2
    See related
    Ensembl:ENSOCUG00000004612
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    CANP 2
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 16 NC_067389.1 (35938806..35985528)

    Chromosome 16 - NC_067389.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127483544 Neighboring gene calpain 8 Neighboring gene uncharacterized LOC103350959 Neighboring gene uncharacterized LOC127483543 Neighboring gene tumor protein p53 binding protein 2 Neighboring gene 60S ribosomal protein L17-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067389.1 Chromosome 16 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease. Emori Y, et al. J Biol Chem, 1986 Jul 15. PMID 2424911
    2. E-F hand structure-domain of calcium-activated neutral protease (CANP) can bind Ca2+ ions. Minami Y, et al. J Biochem, 1987 Apr. PMID 3038855
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-2 catalytic subunit
    Names
    M-calpain
    calcium-activated neutral proteinase 2
    calpain 2, (m/II) large subunit
    calpain M-type
    calpain-2 large subunit
    millimolar-calpain
    NP_001182651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195722.2 → NP_001182651.1  calpain-2 catalytic subunit

      Status: PROVISIONAL

      Source sequence(s)
      VIYN02003005
      UniProtKB/TrEMBL
      G1TKY3
      Related
      ENSOCUP00000017627.2, ENSOCUT00000031272.2
      Conserved Domains (4) summary
      COG5126
      Location:604 → 695
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam00648
      Location:46 → 342
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:356 → 507
      Calpain_III; Calpain large subunit, domain III
      cl08302
      Location:577 → 631
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067389.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      35938806..35985528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06814.1 GenPept UniProtKB/Swiss-Prot:P06814

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