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    Mndal myeloid nuclear differentiation antigen like [ Mus musculus (house mouse) ]

    Gene ID: 100040462, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mndalprovided by MGI
    Official Full Name
    myeloid nuclear differentiation antigen likeprovided by MGI
    Primary source
    MGI:MGI:3780953
    See related
    Ensembl:ENSMUSG00000090272 AllianceGenome:MGI:3780953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm2785; Ifi212
    Summary
    Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Involved in negative regulation of cell growth. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bladder adult (RPKM 3.3), spleen adult (RPKM 2.7) and 18 other tissues See more
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    Genomic context

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    See Mndal in Genome Data Viewer
    Location:
    1 H3; 1 80.71 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173684786..173708038, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173857215..173880382, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interferon activated gene 204 Neighboring gene interferon activated gene 203, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:175731887-175732188 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175783692-175783993 Neighboring gene STARR-seq mESC enhancer starr_03084 Neighboring gene STARR-positive B cell enhancer ABC_E801 Neighboring gene predicted gene, 21031 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene interferon activated gene 211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility. Zhang K, et al. Blood, 2009 Oct 1. PMID 19654412, Free PMC Article
    2. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
    3. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mndal acts as a tumor suppressor and displays haploinsufficiency
      Title: Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myeloid cell nuclear differentiation antigen-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170853.1 → NP_001164324.1  myeloid cell nuclear differentiation antigen-like protein isoform 1

      See identical proteins and their annotated locations for NP_001164324.1

      Status: VALIDATED

      Source sequence(s)
      AK136391, FJ594740
      Consensus CDS
      CCDS48452.1
      UniProtKB/Swiss-Prot
      D0QMC3, D0QMC4
      UniProtKB/TrEMBL
      A0A1Z3MHX2
      Related
      ENSMUSP00000140610.2, ENSMUST00000188804.7
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:311 → 479
      HIN; HIN-200/IF120x domain

    2. NM_001374640.1 → NP_001361569.1  myeloid cell nuclear differentiation antigen-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC170584
      Consensus CDS
      CCDS87927.1
      UniProtKB/TrEMBL
      A0A087WRA4
      Related
      ENSMUSP00000140539.2, ENSMUST00000186442.7
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:258 → 426
      HIN; HIN-200/IF120x domain

    3. NM_001400321.1 → NP_001387250.1  myeloid cell nuclear differentiation antigen-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC170584
      UniProtKB/Swiss-Prot
      D0QMC3, D0QMC4

    4. NM_001400322.1 → NP_001387251.1  myeloid cell nuclear differentiation antigen-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC170584
      UniProtKB/Swiss-Prot
      D0QMC3, D0QMC4

    5. NM_001400323.1 → NP_001387252.1  myeloid cell nuclear differentiation antigen-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC170584

    RNA

    1. NR_174474.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC170584

    2. NR_174475.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC170584

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173684786..173708038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165678.1 → XP_036021571.1  myeloid cell nuclear differentiation antigen-like protein isoform X1

      UniProtKB/Swiss-Prot
      D0QMC3, D0QMC4
      UniProtKB/TrEMBL
      A0A1Z3MHX2
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:311 → 479
      HIN; HIN-200/IF120x domain

    2. XM_036165719.1 → XP_036021612.1  myeloid cell nuclear differentiation antigen-like protein isoform X1

      UniProtKB/Swiss-Prot
      D0QMC3, D0QMC4
      UniProtKB/TrEMBL
      A0A1Z3MHX2
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:311 → 479
      HIN; HIN-200/IF120x domain

    3. XM_036166134.1 → XP_036022027.1  myeloid cell nuclear differentiation antigen-like protein isoform X4

      Conserved Domains (1) summary
      pfam02760
      Location:188 → 356
      HIN; HIN-200/IF120x domain

    4. XM_036152286.1 → XP_036008179.1  myeloid cell nuclear differentiation antigen-like protein isoform X5

      Conserved Domains (1) summary
      pfam02760
      Location:132 → 300
      HIN; HIN-200/IF120x domain

    5. XM_036166009.1 → XP_036021902.1  myeloid cell nuclear differentiation antigen-like protein isoform X3

      UniProtKB/TrEMBL
      A0A087WRA4
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:258 → 426
      HIN; HIN-200/IF120x domain

    6. XM_036165861.1 → XP_036021754.1  myeloid cell nuclear differentiation antigen-like protein isoform X2

      UniProtKB/TrEMBL
      A0A1Z3MHX2
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:311 → 479
      HIN; HIN-200/IF120x domain

    7. XM_036152235.1 → XP_036008128.1  myeloid cell nuclear differentiation antigen-like protein isoform X4

      Conserved Domains (1) summary
      pfam02760
      Location:188 → 356
      HIN; HIN-200/IF120x domain

    8. XM_036165636.1 → XP_036021529.1  myeloid cell nuclear differentiation antigen-like protein isoform X1

      UniProtKB/Swiss-Prot
      D0QMC3, D0QMC4
      UniProtKB/TrEMBL
      A0A1Z3MHX2
      Conserved Domains (2) summary
      cd08305
      Location:9 → 82
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:311 → 479
      HIN; HIN-200/IF120x domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0QMC3.1 GenPept UniProtKB/Swiss-Prot:D0QMC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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