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    Ccdc127 coiled-coil domain containing 127 [ Mus musculus (house mouse) ]

    Gene ID: 67433, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ccdc127provided by MGI
    Official Full Name
    coiled-coil domain containing 127provided by MGI
    Primary source
    MGI:MGI:1914683
    See related
    Ensembl:ENSMUSG00000021578 AllianceGenome:MGI:1914683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430066A18; C130002N06; 0610011N22Rik; 5430420E17Rik
    Summary
    Orthologous to human CCDC127 (coiled-coil domain containing 127). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 14.1), cerebellum adult (RPKM 4.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc127 in Genome Data Viewer
    Location:
    13 C1; 13 40.17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74498436..74513902)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74350317..74365783)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene programmed cell death 6 Neighboring gene succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Neighboring gene STARR-positive B cell enhancer ABC_E10800 Neighboring gene leucine rich repeat containing 14B Neighboring gene zinc finger protein 72 Neighboring gene STARR-seq mESC enhancer starr_35006 Neighboring gene BCL2-like 13 (apoptosis facilitator) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7251 Neighboring gene STARR-seq mESC enhancer starr_35008 Neighboring gene ferritin light polypeptide 1, pseudogene 1 Neighboring gene microRNA 692-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 127

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168658.1 → NP_001162129.1  coiled-coil domain-containing protein 127 isoform 2

      See identical proteins and their annotated locations for NP_001162129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK164539, CT009486
      Consensus CDS
      CCDS49314.1
      UniProtKB/TrEMBL
      E0CYP1
      Related
      ENSMUSP00000124193.2, ENSMUST00000160021.8

    2. NM_001168659.1 → NP_001162130.1  coiled-coil domain-containing protein 127 isoform 1

      See identical proteins and their annotated locations for NP_001162130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK002564, AK164539, CT009486
      Consensus CDS
      CCDS26644.1
      UniProtKB/Swiss-Prot
      Q3TC33, Q3TPA8, Q9CQ15
      UniProtKB/TrEMBL
      E0CYX9
      Related
      ENSMUSP00000022063.8, ENSMUST00000022063.14
      Conserved Domains (1) summary
      pfam17380
      Location:47 → 137
      DUF5401; Family of unknown function (DUF5401)

    3. NM_024201.3 → NP_077163.1  coiled-coil domain-containing protein 127 isoform 1

      See identical proteins and their annotated locations for NP_077163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK164539, BC049099, CT009486
      Consensus CDS
      CCDS26644.1
      UniProtKB/Swiss-Prot
      Q3TC33, Q3TPA8, Q9CQ15
      UniProtKB/TrEMBL
      E0CYX9
      Related
      ENSMUSP00000123805.2, ENSMUST00000162376.2
      Conserved Domains (1) summary
      pfam17380
      Location:47 → 137
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74498436..74513902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TC33.2 GenPept UniProtKB/Swiss-Prot:Q3TC33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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