U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    GAREM2 GRB2 associated regulator of MAPK1 subtype 2 [ Homo sapiens (human) ]

    Gene ID: 150946, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GAREM2provided by HGNC
    Official Full Name
    GRB2 associated regulator of MAPK1 subtype 2provided by HGNC
    Primary source
    HGNC:HGNC:27172
    See related
    Ensembl:ENSG00000157833 MIM:617999; AllianceGenome:HGNC:27172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM59B; GAREML
    Expression
    Broad expression in brain (RPKM 5.7), testis (RPKM 1.0) and 17 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2p23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26173088..26204304)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (26208391..26239634)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26395957..26412532)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26387200-26387378 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26387836-26388007 Neighboring gene peptidylprolyl isomerase like 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26398419-26398957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26401279-26402194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26402195-26403110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11270 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26465316-26465856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26467342-26468022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26468835-26469562 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene adhesion G protein-coupled receptor F3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. Taniguchi T, et al. J Biol Chem, 2013 Oct 11. PMID 24003223, Free PMC Article
    2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Gorbea C, et al. J Biol Chem, 2010 Oct 8. PMID 20682791, Free PMC Article
    3. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Bisson N, et al. Nat Biotechnol, 2011 Jun 26. PMID 21706016
    4. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. Wong KA, et al. PLoS One, 2012. PMID 22558309, Free PMC Article
    5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. Emdal KB, et al. Sci Signal, 2015 Apr 28. PMID 25921289

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ00375, KIAA2038

    General protein information

    Go to the top of the page Help
    Preferred Names
    GRB2-associated and regulator of MAPK protein 2
    Names
    GRB2 associated regulator of MAPK1 2
    GRB2 associated, regulator of MAPK1-like
    GRB2-associated and regulator of MAPK protein-like
    GRB2-associated and regulator of MAPK1-like
    family with sequence similarity 59, member B
    protein FAM59B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168241.2 → NP_001161713.1  GRB2-associated and regulator of MAPK protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001161713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AA736392, AB124552, AC011742, CX759737
      Consensus CDS
      CCDS54336.1
      UniProtKB/Swiss-Prot
      B5MC97, B7WNK9, Q75VX8, Q8NF27, Q9UIK8
      Related
      ENSP00000384593.1, ENST00000401533.7
      Conserved Domains (2) summary
      cd09525
      Location:806 → 872
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:29 → 341
      CABIT; Cell-cycle sustaining, positive selection,

    2. NM_001191033.2 → NP_001177962.1  GRB2-associated and regulator of MAPK protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA736392, AB015349, AC011742, AK090454
      Consensus CDS
      CCDS54337.1
      UniProtKB/Swiss-Prot
      Q75VX8
      Related
      ENSP00000384581.1, ENST00000407684.1
      Conserved Domains (2) summary
      cd09525
      Location:596 → 662
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:7 → 264
      CABIT; Cell-cycle sustaining, positive selection,

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      26173088..26204304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532567.4 → XP_011530869.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

      Conserved Domains (1) summary
      pfam12736
      Location:29 → 341
      CABIT; Cell-cycle sustaining, positive selection,

    2. XM_006711951.5 → XP_006712014.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q75VX8
      Conserved Domains (2) summary
      cd09525
      Location:673 → 739
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:29 → 341
      CABIT; Cell-cycle sustaining, positive selection,

    3. XM_011532565.4 → XP_011530867.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011530867.1

      Conserved Domains (2) summary
      cd09525
      Location:804 → 870
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:36 → 339
      CABIT; Cell-cycle sustaining, positive selection,

    4. XM_011532564.3 → XP_011530866.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011530866.1

      Conserved Domains (2) summary
      cd09525
      Location:804 → 870
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:36 → 339
      CABIT; Cell-cycle sustaining, positive selection,

    5. XM_011532566.3 → XP_011530868.1  GRB2-associated and regulator of MAPK protein 2 isoform X2

      Conserved Domains (2) summary
      cd09525
      Location:687 → 753
      SAM_GAREM; SAM domain of GAREM subfamily
      pfam12736
      Location:1 → 222
      CABIT; Cell-cycle sustaining, positive selection,

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      26208391..26239634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340696.1 → XP_054196671.1  GRB2-associated and regulator of MAPK protein 2 isoform X4

    2. XM_054340695.1 → XP_054196670.1  GRB2-associated and regulator of MAPK protein 2 isoform X3

    3. XM_054340693.1 → XP_054196668.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    4. XM_054340692.1 → XP_054196667.1  GRB2-associated and regulator of MAPK protein 2 isoform X1

    5. XM_054340694.1 → XP_054196669.1  GRB2-associated and regulator of MAPK protein 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q75VX8.3 GenPept UniProtKB/Swiss-Prot:Q75VX8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous