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    Thada THADA, armadillo repeat containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313865, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Thadaprovided by RGD
    Official Full Name
    THADA, armadillo repeat containingprovided by RGD
    Primary source
    RGD:1560519
    See related
    EnsemblRapid:ENSRNOG00000025899 AllianceGenome:RGD:1560519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560519
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration and tRNA nucleoside ribose methylation. Predicted to be located in endoplasmic reticulum. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 125.6), Thymus (RPKM 99.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thada in Genome Data Viewer
    Location:
    6q12
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15936593..16240523)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10183942..10488007)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7423555..7741431, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479315 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H2 Neighboring gene uncharacterized LOC134479314 Neighboring gene uncharacterized LOC108351166 Neighboring gene zinc finger protein 36, C3H type-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. THADA Regulates the Organismal Balance between Energy Storage and Heat Production. Moraru A, et al. Dev Cell, 2017 Apr 10. PMID 28399403, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA nucleoside ribose methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (32-2'-O)-methyltransferase regulator THADA
    Names
    thyroid adenoma associated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191769.2 → NP_001178698.1  tRNA (32-2'-O)-methyltransferase regulator THADA

      See identical proteins and their annotated locations for NP_001178698.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZTM5, D3ZVT2
      Related
      ENSRNOP00000099300.1, ENSRNOT00000162430.1
      Conserved Domains (1) summary
      pfam10350
      Location:943 → 1238
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      15936593..16240523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239705.5 → XP_006239767.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTM5, D3ZVT2
      Related
      ENSRNOP00000032728.4, ENSRNOT00000038246.8
      Conserved Domains (1) summary
      pfam10350
      Location:943 → 1238
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    2. XM_006239707.5 → XP_006239769.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTM5
      Related
      ENSRNOP00000101179.1, ENSRNOT00000150431.1
      Conserved Domains (1) summary
      pfam10350
      Location:943 → 1238
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    3. XM_039112158.2 → XP_038968086.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X5

      Conserved Domains (1) summary
      pfam10350
      Location:938 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    4. XM_063261829.1 → XP_063117899.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X4

    5. XM_039112156.2 → XP_038968084.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X3

      Conserved Domains (1) summary
      pfam10350
      Location:938 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    6. XM_039112159.2 → XP_038968087.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X6

      Conserved Domains (1) summary
      pfam10350
      Location:938 → 1114
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    7. XM_017594120.3 → XP_017449609.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTM5, D3ZVT2
      Conserved Domains (1) summary
      pfam10350
      Location:943 → 1238
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    8. XM_063261828.1 → XP_063117898.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

      UniProtKB/TrEMBL
      D3ZVT2

    RNA

    1. XR_010052081.1 RNA Sequence

    2. XR_005505507.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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