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    P2RY8 P2Y receptor family member 8 [ Homo sapiens (human) ]

    Gene ID: 286530, updated on 2-Nov-2024

    Summary

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    Official Symbol
    P2RY8provided by HGNC
    Official Full Name
    P2Y receptor family member 8provided by HGNC
    Primary source
    HGNC:HGNC:15524
    See related
    Ensembl:ENSG00000182162 Ensembl:ENSG00000292333 MIM:300525; AllianceGenome:HGNC:15524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2Y8
    Summary
    The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 13.9), spleen (RPKM 8.9) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See P2RY8 in Genome Data Viewer
    Location:
    X;Y
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1462581..1537185, complement)
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1462581..1537185, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1325951..1401516, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1581474..1656078, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1531474..1606078, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene A-kinase anchoring protein 17A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1585389-1585889 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1599821-1599989 Neighboring gene hESC enhancers GRCh37_chrX:1600455-1601166 and GRCh37_chrY:1550663-1551162 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene A-kinase anchoring protein 17A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. Fujiwara S, et al. Leuk Lymphoma, 2007 May. PMID 17487742
    2. S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Lu E, et al. Nature, 2019 Mar. PMID 30842656, Free PMC Article
    3. P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance. He Y, et al. J Exp Med, 2022 Jan 3. PMID 34889940, Free PMC Article
    4. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. Cantagrel V, et al. J Med Genet, 2004 Oct. PMID 15466006, Free PMC Article
    5. Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma. Storlazzi CT, et al. Leukemia, 2007 Oct. PMID 17554380

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
      Title: P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
    2. [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
      Title: [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
    3. S-Geranylgeranyl-L-glutathione(GGG) is identified as an intercellular signalling molecule that is involved in organizing and controlling germinal-centre responses; as the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, GGG might have organizing and growth-regulatory roles in multiple human tissues
      Title: S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.
    4. P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia.
      Title: Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia.
    5. P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner.
      Title: The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.
    6. P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone.
      Title: Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL.
    7. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
      Title: Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
    8. Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement.
      Title: Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.
    9. SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma
      Title: Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.
    10. P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia
      Title: Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC50878

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 8
    Names
    G-protein coupled purinergic receptor P2Y8
    purinergic receptor P2Y, G-protein coupled, 8
    purinergic receptor P2Y8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013252.1 RefSeqGene

      Range
      4960..79564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001424186.1 → NP_001411115.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    2. NM_001424187.1 → NP_001411116.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    3. NM_001424188.1 → NP_001411117.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    4. NM_001424189.1 → NP_001411118.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    5. NM_001424190.1 → NP_001411119.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    6. NM_001424191.1 → NP_001411120.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    7. NM_001424192.1 → NP_001411121.1  P2Y purinoceptor 8

      Status: REVIEWED

      Source sequence(s)
      AL683870
      UniProtKB/Swiss-Prot
      Q86VZ1

    8. NM_178129.5 → NP_835230.1  P2Y purinoceptor 8

      See identical proteins and their annotated locations for NP_835230.1

      Status: REVIEWED

      Source sequence(s)
      AI476104, AK092956, AL683870, AL833184, BC043610, BE245848
      Consensus CDS
      CCDS14115.1
      UniProtKB/Swiss-Prot
      Q86VZ1
      Related
      ENSP00000370697.4, ENSP00000518611.1, ENST00000381297.10, ENST00000711216.1
      Conserved Domains (1) summary
      cd15368
      Location:24 → 304
      7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      1462581..1537185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274429.4 → XP_005274486.1  P2Y purinoceptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005274486.1

      UniProtKB/Swiss-Prot
      Q86VZ1
      Conserved Domains (1) summary
      cd15368
      Location:24 → 304
      7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      1462581..1537185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274778.4 → XP_005274835.1  P2Y purinoceptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005274835.1

      UniProtKB/Swiss-Prot
      Q86VZ1
      Conserved Domains (1) summary
      cd15368
      Location:24 → 304
      7tmA_P2Y8; purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      1325951..1401516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328280.1 → XP_054184255.1  P2Y purinoceptor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q86VZ1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VZ1.1 GenPept UniProtKB/Swiss-Prot:Q86VZ1

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