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    Timm17a translocase of inner mitochondrial membrane 17A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54311, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Timm17aprovided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 17Aprovided by RGD
    Primary source
    RGD:3862
    See related
    EnsemblRapid:ENSRNOG00000007040 AllianceGenome:RGD:3862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tim17; Timm17
    Summary
    Enables enzyme binding activity. Involved in positive regulation of protein processing. Located in mitochondrial inner membrane. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Heart (RPKM 965.4), Muscle (RPKM 907.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Timm17a in Genome Data Viewer
    Location:
    13q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49282918..49296363, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46731117..46742604, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52124641..52136127, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene E74 like ETS transcription factor 3 Neighboring gene arginyl aminopeptidase Neighboring gene uncharacterized LOC120096253 Neighboring gene leiomodin 1 Neighboring gene shisa family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the initial steps of precursor import into rat liver mitoplasts. Ishihara N, et al. J Biochem, 1998 Oct. PMID 9756630
    2. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. Ishihara N, et al. J Biochem, 1998 Apr. PMID 9538267
    3. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, et al. Biochim Biophys Acta, 2015 May. PMID 25633533
    4. Unlocking the presequence import pathway. Schulz C, et al. Trends Cell Biol, 2015 May. PMID 25542066
    5. Genetic and structural characterization of the human mitochondrial inner membrane translocase. Bauer MF, et al. J Mol Biol, 1999 May 28. PMID 10339406

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72274

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim17-A
    Names
    inner membrane preprotein translocase Tim17a
    translocase of inner mitochondrial membrane 17 homolog A
    translocator of inner mitochondrial membrane 17 kDa, a
    translocator of inner mitochondrial membrane 17a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019351.2 → NP_062224.1  mitochondrial import inner membrane translocase subunit Tim17-A

      See identical proteins and their annotated locations for NP_062224.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      O35092
      UniProtKB/TrEMBL
      A0A8I6ANA6, A6ICE7
      Related
      ENSRNOP00000009398.6, ENSRNOT00000009398.6
      Conserved Domains (1) summary
      TIGR00980
      Location:1 → 171
      3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49282918..49296363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272562.1 → XP_063128632.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform X1

      UniProtKB/Swiss-Prot
      O35092
      UniProtKB/TrEMBL
      A6ICE7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35092.1 GenPept UniProtKB/Swiss-Prot:O35092

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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