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    Zfp407 zinc finger protein 407 [ Mus musculus (house mouse) ]

    Gene ID: 240476, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp407provided by MGI
    Official Full Name
    zinc finger protein 407provided by MGI
    Primary source
    MGI:MGI:2685179
    See related
    Ensembl:ENSMUSG00000048410 AllianceGenome:MGI:2685179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm333; Gm334; Gm948; ZNF407; 6430585N13Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryo; extraembryonic component; primitive endoderm; and yolk sac. Orthologous to human ZNF407 (zinc finger protein 407). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 1.6), CNS E11.5 (RPKM 1.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp407 in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84225826..84612815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84207701..84589539, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11664 Neighboring gene predicted gene, 31854 Neighboring gene prostaglandin reductase 3 Neighboring gene STARR-seq mESC enhancer starr_45246 Neighboring gene STARR-seq mESC enhancer starr_45247 Neighboring gene predicted gene, 57824 Neighboring gene STARR-seq mESC enhancer starr_45248 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84524711-84525012 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84554442-84554743 Neighboring gene STARR-seq mESC enhancer starr_45250 Neighboring gene predicted gene, 31909 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene carnosine dipeptidase 1 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407. Charrier A, et al. PLoS One, 2024. PMID 38781157, Free PMC Article
    2. Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice. Charrier A, et al. Mol Cell Endocrinol, 2021 Feb 5. PMID 33285243, Free PMC Article
    3. Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. Buchner DA, et al. J Biol Chem, 2015 Mar 6. PMID 25596527, Free PMC Article
    4. Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice. Charrier A, et al. Am J Physiol Endocrinol Metab, 2016 Nov 1. PMID 27624101, Free PMC Article
    5. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular regulation of PPARgamma/RXRalpha signaling by the novel cofactor ZFP407.
      Title: Molecular regulation of PPARγ/RXRα signaling by the novel cofactor ZFP407.
    2. Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice.
      Title: Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice.
    3. transcriptome analysis revealed that ZFP407 regulates many peroxisome proliferator-activated receptor (PPAR) gamma target genes beyond Glut4.
      Title: Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 407

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033341.2 → NP_001028513.2  zinc finger protein 407

      See identical proteins and their annotated locations for NP_001028513.2

      Status: VALIDATED

      Source sequence(s)
      AC124187, AC126021, AC149591, AC152060
      Consensus CDS
      CCDS50338.1
      UniProtKB/TrEMBL
      G3UVV3
      Related
      ENSMUSP00000118361.2, ENSMUST00000125763.3
      Conserved Domains (4) summary
      COG5048
      Location:1703 → 1758
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:1621 → 1641
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1407 → 1436
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1633 → 1660
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84225826..84612815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247079.3 → XP_011245381.1  zinc finger protein 407 isoform X1

      Conserved Domains (4) summary
      sd00017
      Location:1621 → 1641
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1407 → 1436
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1633 → 1660
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1705 → 1729
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_006526470.5 → XP_006526533.1  zinc finger protein 407 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:1530 → 1552
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1407 → 1436
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1548 → 1569
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_877587.3 RNA Sequence

    2. XR_877586.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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