mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mapk8ip3provided by ZNC
Official Full Name: mitogen-activated protein kinase 8 interacting protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-090303-6
See related: Ensembl:ENSDARG00000062531 AllianceGenome:ZFIN:ZDB-GENE-090303-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jip3
Summary: Enables cargo adaptor activity. Acts upstream of or within axon extension; regulation of JNK cascade; and retrograde axonal protein transport. Predicted to be active in cytoplasm. Is expressed in central nervous system; peripheral nervous system; and posterior lateral line ganglion. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (15906894..15988730)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (15757630..15838269)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
Title: JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IEA Inferred from Electronic Annotation more info
enables cargo adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retrograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retrograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 3

Names: JNK-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302244.2 → NP_001289173.2 C-Jun-amino-terminal kinase-interacting protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

BX936333

Related

ENSDARP00000130835.2, ENSDART00000163525.2
NM_001423685.1 → NP_001410614.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

BX936333

Related

ENSDARP00000120365.2, ENSDART00000139206.4
NM_001423686.1 → NP_001410615.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

BX936333
NM_001423687.1 → NP_001410616.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

BX936333